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Literature summary for 2.7.1.6 extracted from
- Substrate specificity of the galactokinase from the human gut symbiont Akkermansia muciniphila ATCC BAA-835 (2020), Enzyme Microb. Technol., 139, 109568 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Akkermansia muciniphila |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | - |
Akkermansia muciniphila |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | 10 mM, slight activation | Akkermansia muciniphila | |
| Ca2+ | 10 mM, slight activation | Akkermansia muciniphila | |
| Mg2+ | 10 mM, the enzyme requires Mg2+ | Akkermansia muciniphila | |
| Ni2+ | 10 mM, slight activation | Akkermansia muciniphila | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-D-galactose | Akkermansia muciniphila | - |
ADP + alpha-D-galactose 1-phosphate | - |
? | |
| ATP + alpha-D-galactose | Akkermansia muciniphila ATCC BAA-835 | - |
ADP + alpha-D-galactose 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Akkermansia muciniphila | B2UQR6 | - |
- |
| Akkermansia muciniphila ATCC BAA-835 | B2UQR6 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Akkermansia muciniphila |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-D-galactose | - |
Akkermansia muciniphila | ADP + alpha-D-galactose 1-phosphate | - |
? | |
| ATP + alpha-D-galactose | - |
Akkermansia muciniphila ATCC BAA-835 | ADP + alpha-D-galactose 1-phosphate | - |
? | |
| ATP + D-galactosamine | 100% of the activity with alpha-D-galactose | Akkermansia muciniphila | ADP + D-galactosamine 1-phosphate | - |
? | |
| ATP + D-galactosamine | 100% of the activity with alpha-D-galactose | Akkermansia muciniphila ATCC BAA-835 | ADP + D-galactosamine 1-phosphate | - |
? | |
| ATP + D-galacturonic acid | 20.2% of the activity with alpha-D-galactose | Akkermansia muciniphila | ADP + D-galacturonic acid 1-phosphate | - |
? | |
| ATP + D-galacturonic acid | 20.2% of the activity with alpha-D-galactose | Akkermansia muciniphila ATCC BAA-835 | ADP + D-galacturonic acid 1-phosphate | - |
? | |
| ATP + D-glucose | 52.5% of the activity with alpha-D-galactose | Akkermansia muciniphila | ADP + alpha-D-glucose 1-phosphate | - |
? | |
| ATP + D-glucose | 52.5% of the activity with alpha-D-galactose | Akkermansia muciniphila ATCC BAA-835 | ADP + alpha-D-glucose 1-phosphate | - |
? | |
| ATP + N-acetyl-D-galactosamine | 15.5% of the activity with alpha-D-galactose | Akkermansia muciniphila | ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
? | |
| ATP + N-acetyl-D-galactosamine | 15.5% of the activity with alpha-D-galactose | Akkermansia muciniphila ATCC BAA-835 | ADP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GalKAmu | - |
Akkermansia muciniphila |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 42 | - |
- |
Akkermansia muciniphila |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | 60 | 37°C: about 65% of maximal activity, 60°C: about 55% of maximal activity | Akkermansia muciniphila |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Akkermansia muciniphila |
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