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Literature summary for 2.7.1.59 extracted from

  • Hinderlich, S.; Berger, M.; Schwarzkopf, M.; Effertz, K.; Reutter, W.
    Molecular cloning and characterization of murine and human N-acetylglucosamine kinase (2000), Eur. J. Biochem., 267, 3301-3308.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens
functionally expressed in Escherichia coli BL21, active enzyme, high rate of protein expression in transfected cells, inclusion bodies Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-acetyl-D-glucosamine inhibition of activity with N-acetyl-D-mannosamine Mus musculus
N-acetyl-D-mannosamine no inhibition of activity with N-acetyl-D-glucosamine Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41000
-
SDS-PAGE, from E. coli Mus musculus
373000
-
calculated from DNA sequence Mus musculus
374000
-
calculated from DNA sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acetyl-D-glucosamine Mus musculus
-
ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
ATP + N-acetyl-D-glucosamine Homo sapiens
-
ADP + N-acetyl-D-glucosamine 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UJ70
-
-
Mus musculus Q9QZ08 sequence with additional 92 bp sequence found in lung, EMBL: AF242911
-

Purification (Commentary)

Purification (Comment) Organism
from E. coli Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
heart
-
Mus musculus
-
heart
-
Homo sapiens
-
kidney
-
Mus musculus
-
kidney
-
Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
lung
-
Mus musculus
-
lung
-
Homo sapiens
-
additional information present in cancer cell lines Homo sapiens
-
muscle
-
Mus musculus
-
muscle
-
Homo sapiens
-
spleen
-
Mus musculus
-
spleen
-
Homo sapiens
-
testis very high activity Mus musculus
-
testis very high activity Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.137
-
enzyme expressed in E. coli, 37°C, pH 7.5 Mus musculus
25
-
purified enzyme from E. coli, 37°C, pH 7.5 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-acetyl-D-glucosamine
-
Mus musculus ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
ATP + N-acetyl-D-glucosamine
-
Homo sapiens ADP + N-acetyl-D-glucosamine 6-phosphate
-
?
ATP + N-acetyl-D-mannosamine recombinant enzyme, same rate as with N-acetyl-D-glucosamine Mus musculus ADP + N-acetyl-D-mannosamine 6-phosphate
-
?
additional information D-fructose, D-mannose, D-maltose, D-galactose, N-acetyl-D-galactosamine, ribose, fucose do not serve as substrates Mus musculus ?
-
?