Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
functionally expressed in Escherichia coli BL21, active enzyme, high rate of protein expression in transfected cells, inclusion bodies | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-acetyl-D-glucosamine | inhibition of activity with N-acetyl-D-mannosamine | Mus musculus | |
N-acetyl-D-mannosamine | no inhibition of activity with N-acetyl-D-glucosamine | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
41000 | - |
SDS-PAGE, from E. coli | Mus musculus |
373000 | - |
calculated from DNA sequence | Mus musculus |
374000 | - |
calculated from DNA sequence | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + N-acetyl-D-glucosamine | Mus musculus | - |
ADP + N-acetyl-D-glucosamine 6-phosphate | - |
? | |
ATP + N-acetyl-D-glucosamine | Homo sapiens | - |
ADP + N-acetyl-D-glucosamine 6-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UJ70 | - |
- |
Mus musculus | Q9QZ08 | sequence with additional 92 bp sequence found in lung, EMBL: AF242911 | - |
Purification (Comment) | Organism |
---|---|
from E. coli | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
heart | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
additional information | present in cancer cell lines | Homo sapiens | - |
muscle | - |
Mus musculus | - |
muscle | - |
Homo sapiens | - |
spleen | - |
Mus musculus | - |
spleen | - |
Homo sapiens | - |
testis | very high activity | Mus musculus | - |
testis | very high activity | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.137 | - |
enzyme expressed in E. coli, 37°C, pH 7.5 | Mus musculus |
25 | - |
purified enzyme from E. coli, 37°C, pH 7.5 | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + N-acetyl-D-glucosamine | - |
Mus musculus | ADP + N-acetyl-D-glucosamine 6-phosphate | - |
? | |
ATP + N-acetyl-D-glucosamine | - |
Homo sapiens | ADP + N-acetyl-D-glucosamine 6-phosphate | - |
? | |
ATP + N-acetyl-D-mannosamine | recombinant enzyme, same rate as with N-acetyl-D-glucosamine | Mus musculus | ADP + N-acetyl-D-mannosamine 6-phosphate | - |
? | |
additional information | D-fructose, D-mannose, D-maltose, D-galactose, N-acetyl-D-galactosamine, ribose, fucose do not serve as substrates | Mus musculus | ? | - |
? |