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Literature summary for 2.7.1.49 extracted from

  • Hwang, S.; Cordova, B.; Abdo, M.; Pfeiffer, F.; Maupin-Furlow, J.
    ThiN as a versatile domain of transcriptional repressors and catalytic enzymes of thiamine biosynthesis (2017), J. Bacteriol., 199, e00810-16 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.49

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Haloferax volcanii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine Haloferax volcanii
-
 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine Haloferax volcanii NCIMB 2012
-
 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine Haloferax volcanii JCM 8879
-
 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine Haloferax volcanii DS2
-
 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine Haloferax volcanii DSM 3757
-
 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine Haloferax volcanii ATCC 29605
-
 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine Haloferax volcanii NBRC 14742
-
 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine Haloferax volcanii VKM B-1768
-
 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii
-
 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii the enzyme is involved in biosynthesis of thiamine ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii NCIMB 2012
-
 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii NCIMB 2012 the enzyme is involved in biosynthesis of thiamine ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii JCM 8879
-
 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii JCM 8879 the enzyme is involved in biosynthesis of thiamine ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii DS2
-
 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii DS2 the enzyme is involved in biosynthesis of thiamine ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii DSM 3757
-
 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii DSM 3757 the enzyme is involved in biosynthesis of thiamine ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii ATCC 29605
-
 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii ATCC 29605 the enzyme is involved in biosynthesis of thiamine ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii NBRC 14742
-
 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii NBRC 14742 the enzyme is involved in biosynthesis of thiamine ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii VKM B-1768
-
 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine Haloferax volcanii VKM B-1768 the enzyme is involved in biosynthesis of thiamine ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?

Organism

Organism UniProt Comment Textmining
Haloferax volcanii D4GV38
-
-
Haloferax volcanii ATCC 29605 D4GV38
-
-
Haloferax volcanii DS2 D4GV38
-
-
Haloferax volcanii DSM 3757 D4GV38
-
-
Haloferax volcanii JCM 8879 D4GV38
-
-
Haloferax volcanii NBRC 14742 D4GV38
-
-
Haloferax volcanii NCIMB 2012 D4GV38
-
-
Haloferax volcanii VKM B-1768 D4GV38
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 Haloferax volcanii ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine reaction of EC 2.7.4.7 Haloferax volcanii ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 Haloferax volcanii NCIMB 2012 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine reaction of EC 2.7.4.7 Haloferax volcanii NCIMB 2012 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 Haloferax volcanii JCM 8879 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine reaction of EC 2.7.4.7 Haloferax volcanii JCM 8879 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 Haloferax volcanii DS2 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine reaction of EC 2.7.4.7 Haloferax volcanii DS2 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 Haloferax volcanii DSM 3757 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine reaction of EC 2.7.4.7 Haloferax volcanii DSM 3757 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 Haloferax volcanii ATCC 29605 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine reaction of EC 2.7.4.7 Haloferax volcanii ATCC 29605 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 Haloferax volcanii NBRC 14742 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine reaction of EC 2.7.4.7 Haloferax volcanii NBRC 14742 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 Haloferax volcanii VKM B-1768 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine reaction of EC 2.7.4.7 Haloferax volcanii VKM B-1768 ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
-
 Haloferax volcanii ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine the enzyme is involved in biosynthesis of thiamine Haloferax volcanii ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
-
 Haloferax volcanii NCIMB 2012 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine the enzyme is involved in biosynthesis of thiamine Haloferax volcanii NCIMB 2012 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
-
 Haloferax volcanii JCM 8879 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine the enzyme is involved in biosynthesis of thiamine Haloferax volcanii JCM 8879 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
-
 Haloferax volcanii DS2 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine the enzyme is involved in biosynthesis of thiamine Haloferax volcanii DS2 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
-
 Haloferax volcanii DSM 3757 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine the enzyme is involved in biosynthesis of thiamine Haloferax volcanii DSM 3757 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
-
 Haloferax volcanii ATCC 29605 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine the enzyme is involved in biosynthesis of thiamine Haloferax volcanii ATCC 29605 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
-
 Haloferax volcanii NBRC 14742 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine the enzyme is involved in biosynthesis of thiamine Haloferax volcanii NBRC 14742 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
-
 Haloferax volcanii VKM B-1768 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine the enzyme is involved in biosynthesis of thiamine Haloferax volcanii VKM B-1768 ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
 ?

Synonyms

Synonyms Comment Organism
HMP-P kinase
-
 Haloferax volcanii
HMP/HMP phosphate kinase
-
 Haloferax volcanii
HVO_2666 locus name Haloferax volcanii
More see also EC 2.7.4.7 Haloferax volcanii
ThiD
-
 Haloferax volcanii

General Information

General Information Comment Organism
evolution ThiN is a versatile domain of transcriptional repressors and catalytic enzymes of thiamine biosynthesis in archaea, residues that distinguish catalytic from noncatalytic ThiN domains, overview. Structural architecture comparisons of ThiD, ThiE, and ThiN domain-containing proteins in select haloarchaea Haloferax volcanii
metabolism the enzyme is involved in the de novo pathway of thiamine biosynthesis in Haloferax volcanii. Thiamine biosynthesis in archaea is regulated by a transcriptional repressor, ThiR, and not by a riboswitch Haloferax volcanii
physiological function the enzyme is involved in biosynthesis of thiamine Haloferax volcanii