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Literature summary for 2.7.1.48 extracted from

  • Shen, G.; He, P.; Mao, Y.; Li, P.; Luh, F.; Ding, G.; Liu, X.; Yen, Y.
    Overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis (2017), J. Breast Cancer, 20, 132-141 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.48

Application

Application Comment Organism
diagnostics prognostic significance of UCK2 gene in patients with breast cancer. UCK2 is required for chexadmosensitivity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene UCK2, located on chromosome 1q22-23.2, i.e. human testis-specific gene TSA903, enzyme expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cytidine Homo sapiens
-
 ADP + CMP
-
 ?
ATP + uridine Homo sapiens
-
 ADP + UMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZX2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell analysis of the correlation between UCK2 gene expression and breast cancer survival, overview Homo sapiens
-
additional information analysis of the differential expression of UCK2 gene in breast cancer tissues, overview Homo sapiens
-
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cytidine
-
 Homo sapiens ADP + CMP
-
 ?
ATP + uridine
-
 Homo sapiens ADP + UMP
-
 ?

Synonyms

Synonyms Comment Organism
UCK2
-
 Homo sapiens
uridine-cytidine kinase 2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis. UCK2, along with other genes involved in the 5-FU anabolic pathway, produces a phenotype of cell sensitivity to 5-FU folxadlowing knockdown Homo sapiens
physiological function uridine-cytidine kinase (UCK) 2 is a rate-limiting enzyme involved in the salvage pathway of pyrimidine-nucleotide biosynxadthesis. Isozyme UCK2 is overexpressed in many types of cancer and may play a crucial role in activating antitumor prodrugs in human cancer cells. The isozyme catalyzes the phosphorylation of urixaddine and cytidine to form uridine monophosphate (UMP) and cytidine monophosphate (CMP) with efficiency 15 to 20fold higher than that of ubiquitously expressed isozyme UCK1 Homo sapiens