Application | Comment | Organism |
---|---|---|
medicine | target for antitumor and antiviral drug design | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed with a glutathione-S-transferase tag | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with Mg2+, ADP, and CMP by sitting drop vapor diffusion method | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CTP | feedback inhibition | Homo sapiens | |
UTP | feedback inhibition | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | bound to enzyme, can be replaced by Sm2+ | Homo sapiens | |
samarium | four binding sites two of which are located in the active sites | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cytidine | Homo sapiens | rate limiting enzyme of the pyrimidine-nucleotide salvage pathway | ADP + CMP | - |
? | |
ATP + uridine | Homo sapiens | rate limiting enzyme of the pyrimidine-nucleotide salvage pathway | ADP + UMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BZX2 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme using glutathione-S-transferase tag | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cytidine | - |
Homo sapiens | ADP + CMP | - |
? | |
ATP + cytidine | rate limiting enzyme of the pyrimidine-nucleotide salvage pathway | Homo sapiens | ADP + CMP | - |
? | |
ATP + uridine | - |
Homo sapiens | ADP + UMP | - |
? | |
ATP + uridine | rate limiting enzyme of the pyrimidine-nucleotide salvage pathway | Homo sapiens | ADP + UMP | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | two asymmetric dimers form a tetramer, crystal structure analysis | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
uridine-cytidine kinase 2 | - |
Homo sapiens |