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Literature summary for 2.7.1.48 extracted from

  • Van Rompay, A.R.; Norda, A.; Linden, K.; Johansson, M.; Karlsson, A.
    Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases (2001), Mol. Pharmacol., 59, 1181-1186.
    View publication on PubMed
Search for more literature for 2.7.1.48

Cloned(Commentary)

Cloned (Comment) Organism
expression of UCK1 and 2 in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 uridine pH 7.6, 37°C, recombinant uridine kinase 2 Homo sapiens
0.086
-
 cytidine pH 7.6, 37°C, recombinant uridine kinase 2 Homo sapiens
0.3
-
 uridine pH 7.6, 37°C, recombinant uridine kinase 1 Homo sapiens
0.3
-
 cytidine pH 7.6, 37°C, recombinant uridine kinase 1 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 x * 30000, recombinant uridine kinase 1 and 2, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZX2 uridine-cytidine kinase 2
-
Homo sapiens Q9HA47 uridine-cytidine kinase 1
-

Source Tissue

Source Tissue Comment Organism Textmining
brain low levels of uridine kinase 1 mRNA Homo sapiens
-
heart uridine kinase 1 mRNA Homo sapiens
-
kidney uridine kinase 1 mRNA Homo sapiens
-
liver uridine kinase 1 mRNA Homo sapiens
-
placenta low levels of uridine kinase 1 mRNA Homo sapiens
-
placenta uridine kinase 2 mRNA Homo sapiens
-
skeletal muscle uridine kinase 1 mRNA Homo sapiens
-
small intestine low levels of uridine kinase 1 mRNA Homo sapiens
-
spleen low levels of uridine kinase 1 mRNA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-thiocytidine recombinant uridine kinase 2, 86% of activity with uridine Homo sapiens ADP + 2-thiocytidine 5'-monophosphate
-
 ?
ATP + 2-thiocytidine recombinant uridine kinase 1, 20% of activity with uridine Homo sapiens ADP + 2-thiocytidine 5'-monophosphate
-
 ?
ATP + 3,4,5,6-tetrahydrouridine recombinant uridine kinase 1, 13% of activity with uridine Homo sapiens ADP + 3,4,5,6-tetrahydrouridine 5'-monophosphate
-
 ?
ATP + 3,4,5,6-tetrahydrouridine recombinant uridine kinase 2, 81% of activity with uridine Homo sapiens ADP + 3,4,5,6-tetrahydrouridine 5'-monophosphate
-
 ?
ATP + 3-deazauridine recombinant uridine kinase 2, 49% of activity with uridine Homo sapiens ADP + 3-deazauridine 5'-monophosphate
-
 ?
ATP + 3-methyluridine recombinant uridine kinase 2, 18% of activity with uridine Homo sapiens ADP + 3-methyluridine 5'-monophosphate
-
 ?
ATP + 4-thiouridine recombinant uridine kinase 1, 122% of activity with uridine Homo sapiens ADP + 4-thiouridine 5'-monophosphate
-
 ?
ATP + 4-thiouridine recombinant uridine kinase 2, 125% of activity with uridine Homo sapiens ADP + 4-thiouridine 5'-monophosphate
-
 ?
ATP + 5-bromouridine recombinant uridine kinase 1, 50% of activity with uridine Homo sapiens ADP + 5-bromouridine 5'-monophosphate
-
 ?
ATP + 5-bromouridine recombinant uridine kinase 2,6% of activity with uridine Homo sapiens ADP + 5-bromouridine 5'-monophosphate
-
 ?
ATP + 5-fluorocytidine recombinant uridine kinase 1, 37% of activity with uridine Homo sapiens ADP + 5-fluorocytidine 5'-monophosphate
-
 ?
ATP + 5-fluorocytidine recombinant uridine kinase 2, 184% of activity with uridine Homo sapiens ADP + 5-fluorocytidine 5'-monophosphate
-
 ?
ATP + 5-fluorouridine recombinant uridine kinase 2, 89% of activity with uridine Homo sapiens ADP + 5-fluorouridine 5'-monophosphate
-
 ?
ATP + 5-hydroxyuridine recombinant uridine kinase 1, 14% of activity with uridine Homo sapiens ADP + 5-hydroxyuridine 5'-monophosphate
-
 ?
ATP + 5-hydroxyuridine recombinant uridine kinase 2, 12% of activity with uridine Homo sapiens ADP + 5-hydroxyuridine 5'-monophosphate
-
 ?
ATP + 5-methoxyuridine recombinant uridine kinase 1, 122% of activity with uridine Homo sapiens ADP + 5-methoxyuridine 5'-monophosphate
-
 ?
ATP + 5-methoxyuridine recombinant uridine kinase 2, 92% of activity with uridine Homo sapiens ADP + 5-methoxyuridine 5'-monophosphate
-
 ?
ATP + 5-methylcytidine recombinant uridine kinase 1, 9% of activity with uridine Homo sapiens ADP + 5-methylcytidine 5'-monophosphate
-
 ?
ATP + 5-methylcytidine recombinant uridine kinase 2, 30% of activity with uridine Homo sapiens ADP + 5-methylcytidine 5'-monophosphate
-
 ?
ATP + 6-azacytidine recombinant uridine kinase 2, 75% of activity with uridine Homo sapiens ADP + 6-azacytidine 5'-monophosphate
-
 ?
ATP + 6-azauridine recombinant uridine kinase 1, 38% of activity with uridine, recombinant uridine kinase 2, 148% of activity with uridine Homo sapiens ADP + 6-azauridine 5'-monophosphate
-
 ?
ATP + cytidine
-
 Homo sapiens ADP + CMP
-
 ?
ATP + N4-acetylcytidine recombinant uridine kinase 1, 142% of activity with uridine Homo sapiens ADP + N4-acetylcytidine 5'-monophosphate
-
 ?
ATP + N4-acetylcytidine recombinant uridine kinase 2, 84% of activity with uridine Homo sapiens ADP + N4-acetylcytidine 5'-monophosphate
-
 ?
ATP + N4-aminocytidine recombinant uridine kinase 1, 20% of activity with uridine Homo sapiens ADP + N4-aminocytidine 5'-monophosphate
-
 ?
ATP + N4-anisoylcytidine recombinant uridine kinase 2, 12% of activity with uridine Homo sapiens ADP + N4-anisoylcytidine 5'-monophosphate
-
 ?
ATP + N4-anisoylcytidine recombinant uridine kinase 1, 20% of activity with uridine Homo sapiens ADP + N4-anisoylcytidine 5'-monophosphate
-
 ?
ATP + N4-benzoylcytidine recombinant uridine kinase 1, 68% of activity with uridine Homo sapiens ADP + N4-benzoylcytidine 5'-monophosphate
-
 ?
ATP + N4-benzoylcytidine recombinant uridine kinase 2, 51% of activity with uridine Homo sapiens ADP + N4-benzoylcytidine 5'-monophosphate
-
 ?
ATP + uridine no activity with adenosine, guanosine and deoxyribonucleotides, no activity with CTP and UTP Homo sapiens ADP + UMP
-
 ?
GTP + uridine
-
 Homo sapiens UMP + GDP
-
 ?

Subunits

Subunits Comment Organism
? x * 30000, recombinant uridine kinase 1 and 2, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
UCK1
-
 Homo sapiens
UCK2
-
 Homo sapiens