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Literature summary for 2.7.1.40 extracted from

  • Chen, Y.L.; Song, J.J.; Chen, X.C.; Xu, W.; Zhi, Q.; Liu, Y.P.; Xu, H.Z.; Pan, J.S.; Ren, J.L.; Guleng, B.
    Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells (2015), World J. Gastroenterol., 21, 9093-9102.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate Homo sapiens
-
ADP + phosphoenolpyruvate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
hepatocellular carcinoma cell
-
Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate
-
Homo sapiens ADP + phosphoenolpyruvate
-
?

Synonyms

Synonyms Comment Organism
PKM2
-
Homo sapiens
pyruvate kinase M2
-
Homo sapiens

General Information

General Information Comment Organism
malfunction depletion of isoform PKM2 suppresses the proliferation of Hep-G2 and Huh-7 cells and enhances the activities of the epidermal growth factor/epidermal growth factor receptor and transforming growth factorbetA1/transforming growth factor receptor signaling pathways Homo sapiens
physiological function isoform PKM2 plasy different roles in modulating the proliferation and metastasis of hepatocellular carcinoma cells Homo sapiens