Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-phenylalanine | the carboxyl group of phosphoenolpyruvate is responsible for energetic coupling with Phe binding in the allosteric sites | Oryctolagus cuniculus | |
additional information | replacing the carboxyl group of the substrate with a methyl alcohol or removing the phosphate altogether greatly reduces substrate affinity. Removal of the carboxyl group is the only modification tested that removes the ability to allosterically reduce the level of Phe binding. Requirement for monovalent and divalent cations for allosteric inhibition | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate | Oryctolagus cuniculus | - |
ADP + phosphoenolpyruvate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate | - |
Oryctolagus cuniculus | ADP + phosphoenolpyruvate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
M1-PYK | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Oryctolagus cuniculus |
General Information | Comment | Organism |
---|---|---|
physiological function | required role of the active site in allosteric regulation involving substrate binding, requirement for monovalent and divalent cations, overview | Oryctolagus cuniculus |