Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.40 extracted from

  • David, C.J.; Chen, M.; Assanah, M.; Canoll, P.; Manley, J.L.
    HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer (2010), Nature, 463, 364-368.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.40

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocytoma cell low-grade astrocytoma Mus musculus
-
brain
-
 Mus musculus
-
C2C12 cell
-
 Mus musculus
-
glioblastoma multiforme cell
-
 Mus musculus
-
pilocytic astrocytoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
 Mus musculus ATP + pyruvate
-
 ?

Synonyms

Synonyms Comment Organism
PKM1 adult pyruvate kinase isoform Mus musculus
PKM2 embryonic pyruvate kinase isoform Mus musculus

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Mus musculus

General Information

General Information Comment Organism
metabolism the embryonic pyruvate kinase isoform PKM2 is almost universally re-expressed in cancer and promotes aerobic glycolysis, whereas the adult isoform PKM1 promotes oxidative phosphorylation Mus musculus