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Literature summary for 2.7.1.40 extracted from

  • Martinez-Balibrea, E.; Plasencia, C.; Gines, A.; Martinez-Cardus, A.; Musulen, E.; Aguilera, R.; Manzano, J.L.; Neamati, N.; Abad, A.
    A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines (2009), Mol. Cancer Ther., 8, 771-778.
    View publication on PubMed

Application

Application Comment Organism
medicine PK-M2 is a predictive marker of response in patients with oxaliplatin-treated colorectal cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphoenolpyruvate Homo sapiens
-
ATP + pyruvate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-29 cell
-
Homo sapiens
-
HTOXAR-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
Homo sapiens ATP + pyruvate
-
?

Synonyms

Synonyms Comment Organism
PK-M2
-
Homo sapiens
pyruvate kinase M2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens PK-M2 is down-regulates in HTOXAR-3 cells, there is a negative correlation between oxaliplatin resistance and PK-M2 mRNA levels down
Homo sapiens oxaliplatin exposure in both HT-29 and HTOXAR-3 cells leads to PK-M2 mRNA up-regulation up