Application | Comment | Organism |
---|---|---|
medicine | PK-M2 is a predictive marker of response in patients with oxaliplatin-treated colorectal cancer | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | Homo sapiens | - |
ATP + pyruvate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-29 cell | - |
Homo sapiens | - |
HTOXAR-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | - |
Homo sapiens | ATP + pyruvate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PK-M2 | - |
Homo sapiens |
pyruvate kinase M2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | PK-M2 is down-regulates in HTOXAR-3 cells, there is a negative correlation between oxaliplatin resistance and PK-M2 mRNA levels | down |
Homo sapiens | oxaliplatin exposure in both HT-29 and HTOXAR-3 cells leads to PK-M2 mRNA up-regulation | up |