Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | overexpression of PIAS3 leads to nuclear localization of M2-PK and the co-localization of this enzyme with PIAS3 in the nucleus | Homo sapiens | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
most of the protein recognized by the anti-M2-PK antibodies runs at 58000 Da, SDS-PAGE | Homo sapiens |
80000 | - |
M2-PK-SUMO-1 conjugate, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
sumoylation | PIAS3 slightly enhances M2-PK sumoylation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
WI-38 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | - |
Homo sapiens | ATP + pyruvate | - |
? | |
additional information | the SUMO-E3 ligase protein PIAS3 (inhibitor of activated STAT3) physically interacts with M2-PK and its isoenzyme M1-PK | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP/pyruvate O'-phosphotransferase | - |
Homo sapiens |
M1-PK | isozyme | Homo sapiens |
M2-PK | isozyme | Homo sapiens |
pyruvate kinase M2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Homo sapiens |