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Literature summary for 2.7.1.40 extracted from

  • Kim, J.Y.; Kim, D.Y.; Ro, J.Y.
    Granule formation in NGF-cultured mast cells is associated with expressions of pyruvate kinase type M2 and annexin I proteins (2008), Int. Arch. Allergy Immunol., 146, 287-297.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57900
-
calculated from amino acid sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HMC-1 cell
-
Homo sapiens
-
mast cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate
-
Homo sapiens ATP + pyruvate
-
?

Synonyms

Synonyms Comment Organism
pyruvate kinase type M2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens calculated from amino acid sequence
-
8

Expression

Organism Comment Expression
Homo sapiens pyruvate kinase activities are increased by 52.4% in nerve growth factor treatment compared to the cells cultured by horse serum media up

General Information

General Information Comment Organism
physiological function pyruvate kinase and annexin I expressed by nerve growth factor contributes to granule formation containing TNF-alpha as well as other mediators in mast cells, which play a major role in allergic diseases via a TrkA/ERK pathway Homo sapiens