Literature summary for 2.7.1.4 extracted from

Roncal Jimenez, C.A.; Ishimoto, T.; Lanaspa, M.A.; Rivard, C.J.; Nakagawa, T.; Ejaz, A.A.; Cicerchi, C.; Inaba, S.; Le, M.; Miyazaki, M.; Glaser, J.; Correa-Rotter, R.; Gonzalez, M.A.; Aragon, A.; Wesseling, C.; Sanchez-Lozada, L.G.; Johnson, R.J.
Fructokinase activity mediates dehydration-induced renal injury (2014), Kidney Int., 86, 294-302.

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Application

Application	Comment	Organism
medicine	wild-type mice that receive delayed hydration develop renal injury, with elevated serum creatinine, increased urinary neutrophil gelatinase-associated lipocalin, proximal tubular injury, and renal inflammation and fibrosis. This is associated with activation of the polyol pathway, with increased renal cortical sorbitol and fructose levels. Fructokinase-knockout mice with delayed hydration are protected from renal injury. Access to sufficient water during the dehydration period can protect mice from developing renal injury. Studies provide a potential mechanism for Mesoamerican nephropathy	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

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Release 2023.1 (January 2023)