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Literature summary for 2.7.1.39 extracted from

  • Kingsbury, J.M.; McCusker, J.H.
    Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation (2010), Eukaryot. Cell, 9, 729-737.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-homoserine
-
Saccharomyces cerevisiae ADP + O-phospho-L-homoserine
-
?
ATP + L-homoserine
-
Candida albicans ADP + O-phospho-L-homoserine
-
?

Synonyms

Synonyms Comment Organism
Thr1p
-
Saccharomyces cerevisiae
Thr1p
-
Candida albicans

General Information

General Information Comment Organism
malfunction homoserine kinase deletion mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation Candida albicans
malfunction homoserine kinase deletion mutants are extremely serum sensitive and hypersensitive to DNA-damaging agents Saccharomyces cerevisiae