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Literature summary for 2.7.1.39 extracted from

  • Zhou, T.; Daugherty, M.; Grishin, N.V.; Osterman, A.L.; Zhang, H.
    Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily (2000), Structure Fold. Des., 8, 1247-1257.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the enzyme with ADP reveals a novel nucleotide binding fold. The N-terminal domain contains an unusual left-handed beta,alpha,beta unit, while the C-terminal domain has a central alpha-beta plait fold with an insertion of four helices Methanocaldococcus jannaschii
crystals are grown by the hanging drop vapor diffusion method Methanocaldococcus jannaschii

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-homoserine
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Methanocaldococcus jannaschii ADP + O-phospho-L-homoserine
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