Literature summary for 2.7.1.36 extracted from

Houten, S.M.; Frenkel, J.; Rijkers, G.T.; Wanders, R.J.; Kuis, W.; Waterham, H.R.
Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome (2002), Hum. Mol. Genet., 11, 3115-3124.

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Protein Variants

Protein Variants	Comment	Organism
I268T	leads in homozygous state to mevalonic aciduria, inactive mevalonate kinase	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
37	-	approx. 50% and 70% loss of activity after 40 min and 90 min, respectively, H20P/V377I double mutant is only slightly more temperature sensitive	Homo sapiens
50	-	approx. 50% and 90% loss of activity after 10 min and 30 min, respectively, H20P/V377I double mutant is only slightly more temperature sensitive	Homo sapiens

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Release 2023.1 (January 2023)