Literature summary for 2.7.1.35 extracted from

Castro-Fernandez, V.; Bravo-Moraga, F.; Ramirez-Sarmiento, C.A.; Guixe, V.
Emergence of pyridoxal phosphorylation through a promiscuous ancestor during the evolution of hydroxymethyl pyrimidine kinases (2014), FEBS Lett., 588, 3068-3073.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P40191	-	-

Synonyms

Synonyms	Comment	Organism
PdxK	-	Escherichia coli

General Information

General Information	Comment	Organism
additional information	experimental resurrection of the last common ancestor of the hydroxymethyl pyrimidine kinase group based on comparison of hydroxymethyl pyrimidine and pyridoxal kinases. Probably the last common ancestor was not able to use pyridoxal under physiological conditions. The pyridoxal kinase activity present in the current bifunctional enzymes must have appeared in a convergent event independently of the pyridoxal kinase activity of pdxY and pdxK genes. Substrate pyridoxal is 8-times less preferred than the phosphorylation of hydroxymethyl pyrimidine by the last ancestor	Escherichia coli

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Release 2023.1 (January 2023)