Literature summary for 2.7.1.35 extracted from

Hwang, I.K.; Yoo, K.Y.; Kim, D.S.; Eum, W.S.; Park, J.K.; Park, J.; Kwon, O.S.; Kang, T.C.; Choi, S.Y.; Won, M.H.
Changes of pyridoxal kinase expression and activity in the gerbil hippocampus following transient forebrain ischemia (2004), Neuroscience, 128, 511-518.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + pyridoxal	Meriones unguiculatus	generates the active form of vitamin B6, which serves as cofactor for many enzymes, increased enzyme activity detected 12-24 h after ischemia, pyridoxal 5'-phosphate essential for the synthesis of some neurotransmitters	ADP + pyridoxal 5'-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Meriones unguiculatus	-	male Mongolian gerbil	-

Purification (Commentary)

Purification (Comment)	Organism
from hippocampal tissue	Meriones unguiculatus

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampal pyramidal layer	from CA1 region, strong immunoreactivity	Meriones unguiculatus	-
hippocampus	regions CA1, CA2/3 and dentate gyrus, increased enzyme activity detected 12-24 h after ischemia	Meriones unguiculatus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + pyridoxal	-	Meriones unguiculatus	ADP + pyridoxal 5'-phosphate	-	?
ATP + pyridoxal	generates the active form of vitamin B6, which serves as cofactor for many enzymes, increased enzyme activity detected 12-24 h after ischemia, pyridoxal 5'-phosphate essential for the synthesis of some neurotransmitters	Meriones unguiculatus	ADP + pyridoxal 5'-phosphate	-	?

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Release 2023.1 (January 2023)