Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-pantothenate | Saccharomyces cerevisiae | - |
ADP + (R)-4'-phosphopantothenate | - |
? | |
ATP + (R)-pantothenate | Saccharomyces cerevisiae ATCC 204508 | - |
ADP + (R)-4'-phosphopantothenate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | Q04430 | - |
- |
Saccharomyces cerevisiae ATCC 204508 | Q04430 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-pantothenate | - |
Saccharomyces cerevisiae | ADP + (R)-4'-phosphopantothenate | - |
? | |
ATP + (R)-pantothenate | - |
Saccharomyces cerevisiae ATCC 204508 | ADP + (R)-4'-phosphopantothenate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cab1 | - |
Saccharomyces cerevisiae |
Cab1p | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | altered pantothenate utilization dramatically alters the susceptibility of yeast cells to ergosterol biosynthesis inhibitors. Inhibition of pantothenic acid utilization synergizes with the activity of the ergosterol molecule-targeting antifungal amphotericin B and antagonizes that of the ergosterol pathway-targeting antifungal drug terbinafine. Inhibition of pantothenate utilization results in reduced susceptibility to terbinafine and enhanced susceptibility to amphotericin B. Inhibition of Cab1p activity results in reduced squalene and lanosterol levels | Saccharomyces cerevisiae |
metabolism | detailed metabolic pathway from pantothenate to ergosterol involving enzyme Cab1, overview | Saccharomyces cerevisiae |
physiological function | the pantothenate kinase Cab1p catalyzes the first step in the metabolism of pantothenic acid for CoA biosynthesis in budding yeast (Saccharomyces cerevisiae), it significantly regulates the levels of sterol intermediates and the activities of ergosterol biosynthesis-targeting antifungals. This regulation is mediated by changes both in the expression of ergosterol biosynthesis genes and in the levels of sterol intermediates. The CoA metabolism controls ergosterol biosynthesis and susceptibility to antifungals | Saccharomyces cerevisiae |