Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21-AI cells | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
sitting drop vapor diffusion method, using 14.4% (w/v) PEG 8000, 20% (v/v) glycerol, 0.08 m sodium cacodylate, pH 6.5, and 0.16 m magnesium acetate | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-difluoro-N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]benzamide | competitive inhibition | Mycobacterium tuberculosis | |
2-chloro-N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]benzamide | competitive inhibition | Mycobacterium tuberculosis | |
2-[(4'-cyano-2-[[4-(pyridin-2-yl)piperazin-1-yl]methyl][1,1'-biphenyl]-4-yl)oxy]-1-oxoethan-1-aminide | non-competitive inhibition | Mycobacterium tuberculosis | |
N-(1-[5-[(4-fluorobenzyl)sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl]ethyl)-2-(trifluoromethyl)benzamide | competitive inhibition | Mycobacterium tuberculosis | |
N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]-2-(trifluoromethyl)benzamide | competitive inhibition | Mycobacterium tuberculosis | |
N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-[(4-fluorophenyl)methyl]-4H-1,2,4-triazol-3-yl)ethyl]-2-(trifluoromethyl)benzamide | competitive inhibition | Mycobacterium tuberculosis | |
[(4'-cyano-2-[[4-(pyridin-2-yl)piperazin-1-yl]methyl][1,1'-biphenyl]-4-yl)oxy]acetic acid | non-competitive inhibition | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-pantothenate | Mycobacterium tuberculosis | - |
ADP + (R)-4'-phosphopantothenate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WPA7 | - |
- |
Purification (Comment) | Organism |
---|---|
nickel-Sepharose column chromatography and Superdex 75 gel filtration | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-pantothenate | - |
Mycobacterium tuberculosis | ADP + (R)-4'-phosphopantothenate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
CoaA | - |
Mycobacterium tuberculosis |
PanK | - |
Mycobacterium tuberculosis |
Rv1092c | - |
Mycobacterium tuberculosis |