Literature summary for 2.7.1.33 extracted from

Zhang, Y.M.; Chohnan, S.; Virga, K.G.; Stevens, R.D.; Ilkayeva, O.R.; Wenner, B.R.; Bain, J.R.; Newgard, C.B.; Lee, R.E.; Rock, C.O.; Jackowski, S.
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis (2007), Chem. Biol., 14, 291-302.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Mus musculus
expression in HEK-293T cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
4-(2,4-dihydroxy-3,3-dimethylbutylamido)butyric acid	competitive inhibitor; competitive inhibitor, IC50: 0.05-0.15 mM	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-
liver	chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
PanK	-	Mus musculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.05	0.15	competitive inhibitor, IC50: 0.05-0.15 mM	Mus musculus	4-(2,4-dihydroxy-3,3-dimethylbutylamido)butyric acid

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Release 2023.1 (January 2023)