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Literature summary for 2.7.1.33 extracted from

  • Nicely, N.I.; Parsonage, D.; Paige, C.; Newton, G.L.; Fahey, R.C.; Leonardi, R.; Jackowski, S.; Mallett, T.C.; Claiborne, A.
    Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology (2007), Biochemistry, 46, 3234-3245.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Bacillus anthracis
expressed in Escherichia coli strain C41(DE3) Bacillus anthracis

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapour diffusion method using 24-26% ethylene glycol Bacillus anthracis
sitting-drop method. The crystal structure of Bacillus anthracis PanK is solved using multiwavelength anomalous dispersion data and refined at a resolution of 2.0 A Bacillus anthracis

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme is not subject to feedback inhibition by CoASH Bacillus anthracis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bacillus anthracis type III PanK in the spore-forming Bacillus anthracis plays an essential role in the novel thiol/disulfide redox biology of this category A biodefense pathogen ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-
Bacillus anthracis Q81VX4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bacillus anthracis
Ni-NTA column chromatography Bacillus anthracis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-pantothenate
-
 Bacillus anthracis ADP + (R)-4'-phosphopantothenate
-
 ?
additional information type III PanK in the spore-forming Bacillus anthracis plays an essential role in the novel thiol/disulfide redox biology of this category A biodefense pathogen Bacillus anthracis ?
-
 ?

Subunits

Subunits Comment Organism
monomer x-ray crystallography Bacillus anthracis

Synonyms

Synonyms Comment Organism
BaPanK
-
 Bacillus anthracis
PanK
-
 Bacillus anthracis
type III pantothenate kinase
-
 Bacillus anthracis

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bacillus anthracis