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Literature summary for 2.7.1.32 extracted from

  • Li, Z.; Wu, G.; van der Veen, J.N.; Hermansson, M.; Vance, D.E.
    Phosphatidylcholine metabolism and choline kinase in human osteoblasts (2014), Biochim. Biophys. Acta, 1841, 859-867.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + choline Homo sapiens
-
 ADP + phosphocholine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35790
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MG-63 cell
-
 Homo sapiens
-
osteoblast
-
 Homo sapiens
-
osteosarcoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + choline
-
 Homo sapiens ADP + phosphocholine
-
 ?

Synonyms

Synonyms Comment Organism
choline kinase alpha
-
 Homo sapiens
CK-alpha
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens choline kinase activity and expression in MG-63 cells are significantly higher than those in primary human osteoblasts up

General Information

General Information Comment Organism
malfunction the silencing of choline kinase alpha reduces cell proliferation. Moreover, pharmacological inhibition of choline kinase activity impairs the mineralization capacity of MG-63 cells Homo sapiens
physiological function choline kinase and its product phosphocholine are required for the normal growth and mineralization of MG-63 cells Homo sapiens