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Literature summary for 2.7.1.30 extracted from

  • Yokobori, S.I.; Nakajima, Y.; Akanuma, S.; Yamagishi, A.
    Birth of archaeal cells molecular phylogenetic analyses of G1P dehydrogenase, G3P dehydrogenases, and glycerol kinase suggest derived features of archaeal membranes having G1P polar lipids (2016), Archaea, 2016, 1802675 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene glpK, phylogenetic analysis Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + glycerol Escherichia coli
-
 ADP + sn-glycerol 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A6F3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycerol
-
 Escherichia coli ADP + sn-glycerol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
GLPK
-
 Escherichia coli

General Information

General Information Comment Organism
evolution Bacteria and Eukarya have cell membranes with sn-glycerol-3-phosphate (G3P), whereas archaeal membranes contain sn-glycerol-1-phosphate (G1P). Determining the time at which cells with either G3P-lipid membranes or G1P-lipid membranes appeared is important for understanding the early evolution of terrestrial life. Reconstructed molecular phylogenetic trees of G1PDH (G1P dehydrogenase, EgsA/AraM), which is responsible for G1P synthesis and G3PDHs (G3P dehydrogenase, GpsA and GlpA/GlpD), and glycerol kinase (GlpK), which is responsible for G3P synthesis. Together with the distribution of these protein-encoding genes among archaeal and bacterial groups, phylogenetic analyses suggest that GlpA/GlpD in the Commonote (the last universal common ancestor of all extant life with a cellular form, Commonote commonote) acquired EgsA (G1PDH) from the archaeal common ancestor (Commonote archaea) and acquired GpsA and GlpK from a bacterial common ancestor (Commonote bacteria). The Commonote probably possessed a G3P-lipid membrane synthesized enzymatically, after which the archaeal lineage acquires G1PDH followed by the replacement of a G3P-lipid membrane with a G1P-lipid membrane. Detailed overview Escherichia coli
metabolism overview of the stereospecific biosynthetic pathways of glycerol 1-phosphate (G1P) and glycerol 3-phosphate (G3P) Escherichia coli
physiological function glycerol kinase (GlpK) is responsible for sn-glycerol 3-phosphate (G3P) synthesis Escherichia coli