Literature summary for 2.7.1.30 extracted from

Yu, P.; Lasagna, M.; Pawlyk, A.C.; Reinhart, G.D.; Pettigrew, D.W.
IIAGlc inhibition of glycerol kinase: a communications network tunes protein motions at the allosteric site (2007), Biochemistry, 46, 12355-12365.

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Protein Variants

Protein Variants	Comment	Organism
I474A	the maximum extent of IIAGlc inhibition is reduced for the mutant enzyme	Escherichia coli
I474C	the maximum extent of IIAGlc inhibition is reduced for the mutant enzyme	Escherichia coli
R479A	the maximum extent of IIAGlc inhibition is reduced for the mutant enzyme	Escherichia coli
R479C	the maximum extent of IIAGlc inhibition is reduced for the mutant enzyme	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
phosphocarrier protein IIAGlc	the unphosphorylated form of the phosphocarrier protein IIAGlc is an allosteric inhibitor of Escherichia coli glycerol kinase	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A6F3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + glycerol	-	Escherichia coli	ADP + sn-glycerol 3-phosphate	-	?

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Release 2023.1 (January 2023)