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Literature summary for 2.7.1.3 extracted from

  • Hwa, J.S.; Kim, H.J.; Goo, B.M.; Park, H.J.; Kim, C.W.; Chung, K.H.; Park, H.C.; Chang, S.H.; Kim, Y.W.; Kim, D.R.; Cho, G.J.; Choi, W.S.; Kang, K.R.
    The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma (2006), Proteomics, 6, 1077-1084.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32730
-
2-D gel analysis Homo sapiens
32730
-
theoretical Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50053
-
-

Source Tissue

Source Tissue Comment Organism Textmining
renal cell carcinoma cell represent the most prevalent cancer of the kidney. The mean ketohexokinase activity in the renal cell carcinoma tissue samples is approximately 1.4fold lower than that in their normal kidney tissue. Ketohexokinase activity is approximately 1.5fold lower in pT3 renal cell carcinoma tissue than that in pT1 renal cell carcinoma tissue. The enzyme activity of tumor in histological grade 3 is 1.8fold lower than for grade 1 tumor(reaction mixture activity assay: acid-treated supernatant (100 microl) containing 10 mM MgCl2, 50 mM TrisHCl, pH 7.4, 10 mM ATP, 50 mM N-acetyl-D-glucosamine, 10 mM D[UL-14C]fructose and water, at 37°C). The expression level of ketohexokinase mRNA is reduced two- to eightfold in nearly all the clear cell renal cell carcinoma tissue samples compared with normal kidney, except for one renal cell carcinoma sample. Homo sapiens
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Synonyms

Synonyms Comment Organism
fructokinase ketohexokinase Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens 2-D gel analysis
-
5.6
Homo sapiens calculated from amino acid sequence
-
5.7