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Literature summary for 2.7.1.24 extracted from

  • Hart, R.J.; Abraham, A.; Aly, A.S.I.
    Genetic characterization of coenzyme A biosynthesis reveals essential distinctive functions during malaria parasite development in blood and mosquito (2017), Front. Cell. Infect. Microbiol., 7, 260 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information experiments to generate a single gene deletion of DPCK in Plasmodium yoelii 17X-NL parasites show that the inability to delete PyPPAT and PyDPCK is not due to a technical reason, nor the inability to access the gene loci, but due to a crucial role that both enzymes play in the growth and/or survival of blood stage parasites in mouse erythrocytes Plasmodium yoelii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 3'-dephospho-CoA Plasmodium yoelii
-
 ADP + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium yoelii A0A077Y9A9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3'-dephospho-CoA
-
 Plasmodium yoelii ADP + CoA
-
 ?

Synonyms

Synonyms Comment Organism
dephospho-CoA kinase
-
 Plasmodium yoelii
DPCK
-
 Plasmodium yoelii

General Information

General Information Comment Organism
evolution all the eukaryotic-type enzymes of CoA de novo biosynthesis pathway are conserved in all Plasmodium species. Unlike mammalian cells and similar to bacteria, the PPAT and DPCK enzymes are encoded on two different genes and not on one gene that encodes a bifunctional protein Plasmodium yoelii
metabolism conservation of CoA biosynthesis pathway in all malaria parasite species. A schematic representation of the canonical biosynthesis pathway of CoA from pantothenate with enzymes PanK (pantothenate kinase), PPCS (phosphopantothenylcysteine synthase), PPCDC (phosphopantothenylcysteine decarboxylase), PPAT (phosphopantetheine adenylyltransferase), and DPCK (dephospho-CoA kinase), respectively. In contrast to the first two enzymes of this pathway, the last two enzymes for CoA biosynthesis are essential for blood stage parasites Plasmodium yoelii
physiological function the enzyme is involved in biosynthesis of CoA, an essential cofactor for all prokaryotes and eukaryotes to support a large number of metabolic processes including fatty acid biosynthesis and oxidation, as well as carbohydrate and amino acid metabolism. PPAT (phosphopantetheine adenylyltransferase), and DPCK (dephospho-CoA kinase) are essential for growth of blood stage parasites Plasmodium yoelii