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Literature summary for 2.7.1.22 extracted from
- The phosphorolysis of nicotinamide riboside (1951), J. Biol. Chem., 193, 497-507.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.28 | - |
phosphate | pH 7.4 | Sus scrofa |  |
| 1.1 | - |
nicotinamide riboside | pH 7.4 | Sus scrofa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate, calcium phosphate gel, alumina gel | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4.25 | - |
- |
Sus scrofa |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -10°C, several weeks, no loss of activity | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + N-ribosylnicotinamide | - |
Sus scrofa | ADP + nicotinamide ribonucleotide | - |
? | |
| phosphate + inosine | - |
Sus scrofa | ? | - |
? | |
| phosphate + nicotinamide riboside | - |
Sus scrofa | nicotinamide + ribose-1-phosphate | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
nicotinamide riboside phosphorolysis | Sus scrofa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 10 | approx. 25% of maximal activity at pH 6.0, approx. 55% of maximal activity at pH 10, nicotinamide riboside phosphorolysis | Sus scrofa |
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Release 2023.1 (January 2023)
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