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Literature summary for 2.7.1.21 extracted from
- The expression and activity of thymidine kinase 1 and deoxycytidine kinase are modulated by hydrogen peroxide and nucleoside analogs (2020), Nucleosides Nucleotides Nucleic Acids, 39, 1347-1358 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-fluoro-2'-deoxyuridine | concentration dependent reduction of activity | Homo sapiens |  |
| trifluridine | concentration dependent reduction of activity | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P04183 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thymidine kinase 1 | - |
Homo sapiens |
| TK1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | trifluridine and 5-fluoro-2'-deoxyuridine lead to concentration dependent reduction of thymidine kinase 1 expression | down |
| Homo sapiens | doxorubicin treatment leads to upregulation of thymidine kinase 1 | up |
| Homo sapiens | treatment with hydrogen peroxide results in induction of thymidine kinase 1, however, the thymidine kinase 1 activity does not correlate with thymidine kinase 1 protein levels, indicating that TK1 protein is inactive | up |
| Homo sapiens | upregulated after araC and dFdC treatment | up |
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