Literature summary for 2.7.1.21 extracted from

Jagarlamudi, K.; Hansson, L.; Eriksson, S.
Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: Implications of using serum TK1 as a biomarker (2015), BMC Cancer, 15, 66.

Search for more literature for 2.7.1.21

Application

Application	Comment	Organism
medicine	mean serum TK1 activities in sera from myelodysplastic syndrome, breast and prostate cancer patients are 11, 6.7 and 1.8 pmol/min/ml, differing significantly from blood donors (mean value 1.1 pmol/min/ml). Serum TK1 protein levels are also significantly higher in myelodysplastic syndrome, breast, prostate cancer patients compared to blood donors. The detected active TK1 is primarily a high molecular weight complex, similar to the forms found in sera from myelodysplastic syndrome patients and blood donors. High TK1 25 kDa protein levels are found in fractions lacking TK1 activity in sera from cases with breast and prostate cancer	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
25000	-	x * 25000, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P04183	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 25000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
TK1	-	Homo sapiens

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Release 2023.1 (January 2023)