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Literature summary for 2.7.1.21 extracted from

  • Perez-Perez, M.J.; Priego, E.M.; Hernandez, A.I.; Familiar, O.; Camarasa, M.J.; Negri, A.; Gago, F.; Balzarini, J.
    Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future (2008), Med. Res. Rev., 28, 797-820.
    View publication on PubMed
Search for more literature for 2.7.1.21

Inhibitors

Inhibitors Comment Organism Structure
(E)-5-(2-bromovinyl)-1-beta-D-(arabinofuranosyl)uracil
-
 Homo sapiens
1-beta-D-(arabinofuranosyl)thymine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information TK2 is constitutively expressed along the cell cycle and often is virtually the only thymidine kinase that is physiologically active in non-proliferating and resting cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [methyl-3H]thymidine
-
 Homo sapiens ADP + [methyl-3H]thymidine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
thymidine kinase 2
-
 Homo sapiens
TK2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.043
-
-
 Homo sapiens (E)-5-(2-bromovinyl)-1-beta-D-(arabinofuranosyl)uracil
0.285
-
-
 Homo sapiens 1-beta-D-(arabinofuranosyl)thymine