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Literature summary for 2.7.1.21 extracted from

  • Gustafson, E.A.; Chillemi, A.C.; Sage, D.R.; Fingeroth, J.D.
    The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase (1998), Antimicrob. Agents Chemother., 42, 2923-2931.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.21

Cloned(Commentary)

Cloned (Comment) Organism
glutathione S-transferase fusion protein Herpes simplex virus
glutathione S-transferase fusion protein Human gammaherpesvirus 4

Inhibitors

Inhibitors Comment Organism Structure
5-bromodeoxyuridine
-
 Human gammaherpesvirus 4
sorivudine
-
 Human gammaherpesvirus 4
stavudine
-
 Human gammaherpesvirus 4
zidovudine
-
 Human gammaherpesvirus 4

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 SDS-PAGE Herpes simplex virus
70000
-
 SDS-PAGE Human gammaherpesvirus 4

Organism

Organism UniProt Comment Textmining
Herpes simplex virus
-
 type 1
-
Human gammaherpesvirus 4
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Herpes simplex virus
wild type and a truncated form missing 243 N-terminal amino acids Human gammaherpesvirus 4

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + thymidine
-
 Herpes simplex virus ADP + dTMP
-
 ?
ATP + thymidine
-
 Human gammaherpesvirus 4 ADP + dTMP
-
 ?
additional information no substrates: ganciclovir, acyclovir, 2'-deoxycytidine Human gammaherpesvirus 4 ?
-
 ?