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Literature summary for 2.7.1.21 extracted from

  • Berenstein, D.; Christensen, J.F.; Kristensen, T.; Hofbauer, R.; Munch-Petersen, B.
    Valine, not methionine, is amino acid 106 in human cytosolic thymidine kinase (TK1). Impact on oligomerization, stability, and kinetic properties (2000), J. Biol. Chem., 275, 32187-32192.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
V106M results in tetrameric structure with high thymidine affinity Homo sapiens

General Stability

General Stability Organism
stable in the presence of ATP, bovine serum albumin and CHAPS Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
thymidine pH 8 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
2 * 25000, rLyTK1Val-106 Homo sapiens
25000
-
4 * 25000, rLyTK1Met-106 Homo sapiens
50000
-
rLyTK1Val-106, gel filtration Homo sapiens
100000
-
rLyTK1Met-106, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
rLyTK1Val-106 and rLyTK1Met-106 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte healthy and leucemic cells Homo sapiens
-

Subunits

Subunits Comment Organism
dimer 2 * 25000, rLyTK1Val-106 Homo sapiens
tetramer 4 * 25000, rLyTK1Met-106 Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
15
-
rLyTK1Met-106: 50% loss of activity within 41 min, rLyTK1Val-106: 50% loss of activity after 392 min Homo sapiens
25
-
50% loss of activity within 4 min, rLyTK1Met-106 Homo sapiens