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Literature summary for 2.7.1.21 extracted from
- Mechanism of inhibition of thymidine kinase from Escherichia coli by caffeine (1980), FEBS Lett., 110, 223-226.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dCDP | activation | Escherichia coli |  |
| dCTP | activation | Escherichia coli | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenine | - |
Escherichia coli | |
| Caffeine | competitive to ATP, 75% inhibition at 20 mM | Escherichia coli | |
| theophylline | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + thymidine | ATP can be substituted by dATP | Escherichia coli | ADP + dTMP | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 7.5 | - |
Caffeine | pH 7.8, 37°C | Escherichia coli | |
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