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Literature summary for 2.7.1.20 extracted from

  • de Oliveira, R.R.; Morales-Neto, R.; Rocco, S.A.; Sforca, M.L.; Polo, C.C.; Tonoli, C.C.C.; Mercaldi, G.F.; Cordeiro, A.T.; Murakami, M.T.; Franchini, K.G.
    Adenosine kinase couples sensing of cellular potassium depletion to purine metabolism (2018), Sci. Rep., 8, 11988 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.20

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21(DE3) Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method, crystal structures of binary complex with adenosine at 1.2 A and of ternary complex with ADP and adenosine at 1.8 A Mus musculus

Protein Variants

Protein Variants Comment Organism
D310A catalytically deficient mutant that looses responsiveness to K+ Mus musculus
D310P catalytically deficient mutant that looses responsiveness to K+ Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ allosteric activator, it increases the catalytic turnover (Kcat) but does not affect the affinity of the enzyme for adenosine or ATP Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + adenosine Mus musculus
-
 ADP + AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P55264
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
 Mus musculus ADP + AMP
-
 ?

Synonyms

Synonyms Comment Organism
ADK
-
 Mus musculus