Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2R,3S,4R,5S)-4-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 82.5% inhibition | Homo sapiens | |
(1R,2R,3S,4R,5S)-4-(4-anilino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 85.4% inhibition | Homo sapiens | |
(1R,2S,3R,4R,5S)-1-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(aminomethyl)bicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 50.9% inhibition | Homo sapiens | |
(1R,2S,3R,4R,5S)-1-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(azidomethyl)bicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 80.5% inhibition | Homo sapiens | |
(1R,2S,3R,4R,5S)-1-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 58.2% inhibition | Homo sapiens | |
(1R,2S,3R,4R,5S)-1-(4-anilino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 85.1% inhibition | Homo sapiens | |
(1R,2S,3R,4R,5S)-1-(4-anilino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 88.3% inhibition | Homo sapiens | |
(1R,2S,3R,4R,5S)-1-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 76.5% inhibition | Homo sapiens | |
(1R,2S,3R,4S,5S)-1-(4-anilino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-methylbicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 88.1% inhibition | Homo sapiens | |
(1R,2S,3R,4S,5S)-1-[4-(4-fluoroanilino)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylbicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 86.9% inhibition | Homo sapiens | |
(1R,2S,3R,4S,5S)-1-[4-anilino-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylbicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 78.4% inhibition | Homo sapiens | |
(1R,2S,3R,4S,5S)-4-amino-1-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)bicyclo[3.1.0]hexane-2,3-diol | 0.05 mM, 60.4% inhibition | Homo sapiens | |
(1S,2R,3S,5R)-3-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol | 0.05 mM, 88.4% inhibition | Homo sapiens | |
5-iodo-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | 0.05 mM, 88.3% inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine | Homo sapiens | - |
ADP + AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P55263 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine | - |
Homo sapiens | ADP + AMP | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000048 | - |
37°C, pH not specified in the publication | Homo sapiens | (1S,2R,3S,5R)-3-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol | |
0.000088 | - |
37°C, pH not specified in the publication | Homo sapiens | (1R,2S,3R,4S,5S)-1-(4-anilino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-methylbicyclo[3.1.0]hexane-2,3-diol | |
0.00011 | - |
37°C, pH not specified in the publication | Homo sapiens | (1R,2S,3R,4S,5S)-1-[4-(4-fluoroanilino)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylbicyclo[3.1.0]hexane-2,3-diol | |
0.000114 | - |
37°C, pH not specified in the publication | Homo sapiens | (1R,2S,3R,4R,5S)-1-(4-anilino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | |
0.000115 | - |
37°C, pH not specified in the publication | Homo sapiens | (1R,2S,3R,4S,5S)-1-[4-anilino-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylbicyclo[3.1.0]hexane-2,3-diol | |
0.00014 | - |
37°C, pH not specified in the publication | Homo sapiens | (1R,2R,3S,4R,5S)-4-(4-anilino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | |
0.00082 | - |
37°C, pH not specified in the publication | Homo sapiens | 5-iodo-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | |
0.00224 | - |
37°C, pH not specified in the publication | Homo sapiens | (1R,2R,3S,4R,5S)-4-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | |
0.00334 | - |
37°C, pH not specified in the publication | Homo sapiens | (1R,2S,3R,4R,5S)-1-(4-anilino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol | |
0.00538 | - |
37°C, pH not specified in the publication | Homo sapiens | (1R,2S,3R,4R,5S)-1-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(azidomethyl)bicyclo[3.1.0]hexane-2,3-diol | |
0.00601 | - |
37°C, pH not specified in the publication | Homo sapiens | (1R,2S,3R,4R,5S)-1-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol |
General Information | Comment | Organism |
---|---|---|
drug target | adenosine kinase inhibitors raise endogenous adenosine levels, particularly in disease states, and have potential for treatment of seizures, neurodegeneration, and inflammation | Homo sapiens |