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Literature summary for 2.7.1.20 extracted from

  • Butini, S.; Gemma, S.; Brindisi, M.; Borrelli, G.; Lossani, A.; Ponte, A.M.; Torti, A.; Maga, G.; Marinelli, L.; La Pietra, V.; Fiorini, I.; Lamponi, S.; Campiani, G.; Zisterer, D.M.; Nathwani, S.M.; Sartini, S.; La Motta, C.; Da Settimo, F.; Novellino, E.; Focher, F.
    Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies (2011), J. Med. Chem., 54, 1401-1420.
    View publication on PubMed
Search for more literature for 2.7.1.20

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH5alpha cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(+)-6-ethyl-6-[4-[(2,6-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2,3,5,6-tetrafluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2,3-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2,4-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2,4-difluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2,5-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2,5-dimethoxyphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2,6-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-chloro-4-fluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-chloro-4-iodophenyloxy)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-chloro-4-iodophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one 6.5% inhibition at 0.015 mM Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-fluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-imidazolylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-methyl-6-chlorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-pyrazylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-pyridylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(2-pyrimidylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(3,4-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(3-chloro-4-fluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(3-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(3-fluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(3-methoxyphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(3-methylphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(3-trifluoromethoxyphenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo [1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(3-trifluoromethylphenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(4-bromophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(4-ethynylphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one 16% inhibition at 0.015 mM Homo sapiens
(+/-)-6-ethyl-6-[4-[(4-fluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one 13% inhibition at 0.015 mM Homo sapiens
(+/-)-6-ethyl-6-[4-[(4-iodophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(4-iodophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(4-methoxyphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(4-nitrophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(4-trifluoromethoxyphenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one 15% inhibition at 0.015 mM Homo sapiens
(+/-)-6-ethyl-6-[4-[3-(2-diethylaminoethyl)phenoxymethyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[3-(2-hydroxye)thylphenoxymethyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[3-(2-pyrrolidin-1-ylethyl)phenoxymethyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[[4-[2-(trimethylsilyl)ethynyl]phenylthio]-methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-ethyl-6-[4-[[4-[2-(trimethylsilyl)ethynyl]phenylthio]-methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7-one
-
 Homo sapiens
(+/-)-6-[4-[(2-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-[4-[(3-trifluoromethylphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(+/-)-6-[4-[(phenylthio)methyl]phenyl]-6,7-dihydrobenzo-[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
(-)-6-ethyl-6-[4-[(2,6-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
-
 Homo sapiens
10-(dimethylamino)-6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one
-
 Homo sapiens
6-ethyl-6-(3-methylphenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
-
 Homo sapiens
6-ethyl-6-(4-methylphenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
-
 Homo sapiens
6-ethyl-6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
-
 Homo sapiens
6-phenyl-6,7-dihydropyrrolo[2,1-d][1,5]benzothiazepin-7-yl acetate
-
 Homo sapiens
6-phenyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepin-7-yl acetate
-
 Homo sapiens
6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one
-
 Homo sapiens
6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
 adenosine at pH 7.5 and 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast cell line Cen3tel cell Homo sapiens
-
HeLa-S3 cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
 Homo sapiens ADP + AMP
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.5
-
 adenosine at pH 7.5 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.001
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(4-fluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0012
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0012
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-chloro-4-iodophenyloxy)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.002
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(4-bromophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.002
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-chloro-4-iodophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.002
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[[4-[2-(trimethylsilyl)ethynyl]phenylthio]-methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7-one
0.0022
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(4-iodophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7-one
0.0025
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(3-trifluoromethylphenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0025
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(4-iodophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0025
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-chloro-4-fluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.003
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-methyl-6-chlorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.003
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2,3-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0032
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(3-trifluoromethoxyphenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo [1,2-d][1,4]oxazepin-7-one
0.0035
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(3-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0035
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-imidazolylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.004
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(3-fluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.004
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-[4-[(phenylthio)methyl]phenyl]-6,7-dihydrobenzo-[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0044
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-[4-[(2-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0045
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-fluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0045
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-pyridylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.005
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7-one
0.0062
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(4-nitrophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0067
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(4-trifluoromethoxyphenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.007
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-pyrazylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.007
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2-pyrimidylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0075
-
 at pH 7.5 and 37°C Homo sapiens (+)-6-ethyl-6-[4-[(2,6-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.008
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2,3,5,6-tetrafluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.008
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[3-(2-hydroxye)thylphenoxymethyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.009
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-[4-[(3-trifluoromethylphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.01
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[[4-[2-(trimethylsilyl)ethynyl]phenylthio]-methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.01
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(3,4-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.01
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2,4-difluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.011
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(3-chloro-4-fluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0125
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(3-methoxyphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.014
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(4-methoxyphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.014
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2,5-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.015
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(4-ethynylphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.02
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2,6-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0214
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(3-methylphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.0225
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2,4-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.035
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[(2,5-dimethoxyphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.04
-
 at pH 7.5 and 37°C Homo sapiens (-)-6-ethyl-6-[4-[(2,6-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.08
-
 at pH 7.5 and 37°C Homo sapiens 6-ethyl-6-(4-methylphenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
0.085
-
 at pH 7.5 and 37°C Homo sapiens 6-ethyl-6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
0.1
-
 at pH 7.5 and 37°C Homo sapiens 6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
0.13
-
 at pH 7.5 and 37°C Homo sapiens 6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one
0.15
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[3-(2-pyrrolidin-1-ylethyl)phenoxymethyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
0.15
-
 at pH 7.5 and 37°C Homo sapiens 6-ethyl-6-(3-methylphenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
0.2
-
 at pH 7.5 and 37°C Homo sapiens (+/-)-6-ethyl-6-[4-[3-(2-diethylaminoethyl)phenoxymethyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
1
-
 IC50 above 1 mM, at pH 7.5 and 37°C Homo sapiens 10-(dimethylamino)-6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1250
-
 adenosine at pH 7.5 and 37°C Homo sapiens