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Literature summary for 2.7.1.20 extracted from

  • Al Safarjalani, O.N.; Rais, R.H.; Kim, Y.A.; Chu, C.K.; Naguib, F.N.; El Kouni, M.H.
    Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: biological activities and selective toxicities (2010), Biochem. Pharmacol., 80, 955-963.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.20

Inhibitors

Inhibitors Comment Organism Structure
6-benzylthioinosine
-
 Toxoplasma gondii
carbocyclic 6-(2,3,4-trimethylbenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(2,4-dichlorobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(2-chloro-6-fluorobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(2-chlorobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(2-fluorobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(2-methylbenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(3,4-dichlorobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(3-methylbenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(3-nitrobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(3-trifluoromethylbenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(4-bromobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(4-chlorobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(4-cyanobenzylthio)inosine weakest inhibitor Toxoplasma gondii
carbocyclic 6-(4-fluorobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(4-methoxybenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(4-methoxycarbonylbenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(4-methylbenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(4-methylsulfonylbenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(4-nitrobenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(4-trifluoromethoxybenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-(p-methoxycarbonylbenzylthio)inosine
-
 Toxoplasma gondii
carbocyclic 6-benzylthioinosine
-
 Toxoplasma gondii
pyrimethamine
-
 Toxoplasma gondii
Sulfadiazine
-
 Toxoplasma gondii

Organism

Organism UniProt Comment Textmining
Toxoplasma gondii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
 Toxoplasma gondii ADP + AMP
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0119
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(4-methylbenzylthio)inosine
0.0121
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(4-methoxybenzylthio)inosine
0.0128
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(p-methoxycarbonylbenzylthio)inosine
0.0136
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(2-chloro-6-fluorobenzylthio)inosine
0.0144
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(3,4-dichlorobenzylthio)inosine
0.0145
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(4-chlorobenzylthio)inosine
0.0146
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(4-methylsulfonylbenzylthio)inosine
0.0161
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii pyrimethamine
0.0161
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(2,3,4-trimethylbenzylthio)inosine
0.0183
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(4-bromobenzylthio)inosine
0.0186
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(2,4-dichlorobenzylthio)inosine
0.0191
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-benzylthioinosine
0.0191
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(3-trifluoromethylbenzylthio)inosine
0.0197
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(2-methylbenzylthio)inosine
0.0197
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(3-nitrobenzylthio)inosine
0.02
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(2-chlorobenzylthio)inosine
0.0204
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii 6-benzylthioinosine
0.021
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(4-trifluoromethoxybenzylthio)inosine
0.0232
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(4-fluorobenzylthio)inosine
0.0238
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(3-methylbenzylthio)inosine
0.0273
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii Sulfadiazine
0.0389
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(2-fluorobenzylthio)inosine
0.0428
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(4-nitrobenzylthio)inosine
0.049
-
 in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C Toxoplasma gondii carbocyclic 6-(4-cyanobenzylthio)inosine