Literature summary for 2.7.1.20 extracted from

Studer, F.E.; Fedele, D.E.; Marowsky, A.; Schwerdel, C.; Wernli, K.; Vogt, K.; Fritschy, J.M.; Boison, D.
Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme (2006), Neuroscience, 142, 125-137.

Search for more literature for 2.7.1.20

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	expressed most strongly in astrocytes	Mus musculus	-
brain	at early postnatal stages ADK immunoreactivity is prominent in neurons, notably in cerebral cortex and hippocampus. Thereafter, adenosine kinase gradually disappears from neurons and appears in newly developed nestin- and glial fibrillary acidic protein-positive astrocytes. The region-specific downregulation of neuronal adenosine kinase coincides with the onset of myelination. After postnatal day 14, the transition from neuronal to astrocytic ADK expression is complete, except in a subset of neurons that retain ADK until adulthood in specific regions, such as the striatum	Mus musculus	-
cerebral cortex	-	Mus musculus	-
hippocampus	-	Mus musculus	-
neuron	ADK expression in young neurons may provide a salvage pathway to utilize adenosine in nucleic acid synthesis	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
ADK	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)