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Literature summary for 2.7.1.20 extracted from

  • Long, M.C.; Allan, P.W.; Luo, M.Z.; Liu, M.C.; Sartorelli, A.C.; Parker, W.B.
    Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth (2007), J. Antimicrob. Chemother., 59, 118-121.
    View publication on PubMed
Search for more literature for 2.7.1.20

Inhibitors

Inhibitors Comment Organism Structure
2,3-difluoro-3-deaza-7-iso-adenosine 0.1 mM, 18% inhibition Homo sapiens
2,3-difluoro-3-deaza-7-iso-adenosine 0.1 mM, 4% inhibition Mycobacterium tuberculosis
2,3-difluoro-3-deaza-7-isoadenosine 0.1 mM, 18% inhibition of phosphorylation of adenosine Homo sapiens
2,3-difluoro-3-deaza-adenosine 0.1 mM, 12% inhibition Homo sapiens
2,3-difluoro-3-deazaadenosine 0.1 mM, 12% inhibition of phosphorylation of adenosine Homo sapiens
2-fluoro-3-deaza-adenosine 0.1 mM, 9% inhibition Homo sapiens
2-fluoro-3-deaza-adenosine 0.1 mM, 16% inhibition Mycobacterium tuberculosis
2-fluoro-3-deaza-N6-methyl-adenosine 0.1 mM, 13% inhibition; 0.1 mM, 13% inhibition of phosphorylation of adenosine Homo sapiens
2-fluoro-3-deaza-N6-methyl-adenosine 0.1 mM, 37% inhibition; 0.1 mM, 37% inhibition of phosphorylation of adenosine Mycobacterium tuberculosis
2-fluoro-3-deazaadenosine 0.1 mM, 9% inhibition of phosphorylation of adenosine Homo sapiens
2-fluoro-3-deazaadenosine 0.1 mM, 16% inhibition of phosphorylation of adenosine Mycobacterium tuberculosis
3-chloro-3-deaza-adenosine 0.1 mM, 9% inhibition Homo sapiens
3-chloro-3-deaza-adenosine 0.1 mM, 71% inhibition Mycobacterium tuberculosis
3-chloro-3-deazaadenosine 0.1 mM, 9% inhibition of phosphorylation of adenosine Homo sapiens
3-chloro-3-deazaadenosine 0.1 mM, 71% inhibition of phosphorylation of adenosine Mycobacterium tuberculosis
3-deaza-adenosine 0.1 mM, 6% inhibition Homo sapiens
3-deazaadenosine 0.1 mM, 6% inhibition of phosphorylation of adenosine Homo sapiens
3-fluoro-3-deaza-adenosine 0.1 mM, 12% inhibition Homo sapiens
3-fluoro-3-deazaadenosine 0.1 mM, 12% inhibition of phosphorylation of adenosine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mycobacterium tuberculosis
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.001
-
 substrate: 2,3-difluoro-3-deaza-7-isoadenosine Mycobacterium tuberculosis
0.001
-
 substrate: 3-deazaadenosine Mycobacterium tuberculosis
0.001
-
 substrate: 3-fluoro-3-deazaadenosine Homo sapiens
0.005
-
 substrate: 2,3-difluoro-3-deaza-7-isoadenosine Homo sapiens
0.006
-
 substrate: 2,3-difluoro-3-deazaadenosine Homo sapiens
0.016
-
 substrate: 3-fluoro-3-deazaadenosine Mycobacterium tuberculosis
0.063
-
 substrate: 2-fluoro-3-deazaadenosine Mycobacterium tuberculosis
0.081
-
 substrate: 2,3-difluoro-3-deazaadenosine Mycobacterium tuberculosis
2.7
-
 substrate: adenosine Homo sapiens
3.7
-
 substrate: adenosine Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2,3-difluoro-3-deaza-7-iso-adenosine 0.03% of the activity with adenosine Mycobacterium tuberculosis ADP + 2,3-difluoro-3-deaza-7-iso-AMP
-
 ?
ATP + 2,3-difluoro-3-deaza-7-iso-adenosine 0.2% of the activity with adenosine Homo sapiens ADP + 2,3-difluoro-3-deaza-7-iso-AMP
-
 ?
ATP + 2,3-difluoro-3-deaza-7-isoadenosine specific activity1 1 nM/mg/min Mycobacterium tuberculosis ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate
-
 ?
ATP + 2,3-difluoro-3-deaza-7-isoadenosine specific activity: 5 nM/mg/min Homo sapiens ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate
-
 ?
ATP + 2,3-difluoro-3-deaza-adenosine 0.2% of the activity with adenosine Homo sapiens ADP + 2,3-difluoro-3-deaza-AMP
-
 ?
ATP + 2,3-difluoro-3-deaza-adenosine 2.2% of the activity with adenosine Mycobacterium tuberculosis ADP + 2,3-difluoro-3-deaza-AMP
-
 ?
ATP + 2,3-difluoro-3-deazaadenosine specific activity 81 nM/mg/min Mycobacterium tuberculosis ADP + 2,3-difluoro-3-deazaadenosine 5'-phosphate
-
 ?
ATP + 2,3-difluoro-3-deazaadenosine specific activity: 1 nM/mg/min Homo sapiens ADP + 2,3-difluoro-3-deazaadenosine 5'-phosphate
-
 ?
ATP + 2-fluoro-3-deaza-adenosine 1.7% of the activity with adenosine Mycobacterium tuberculosis ADP + 2-fluoro-3-deaza-AMP
-
 ?
ATP + 2-fluoro-3-deazaadenosine specific activity 63 nM/mg/min Mycobacterium tuberculosis ADP + 2-fluoro-3-deazaadenosine 5'-phosphate
-
 ?
ATP + 3-deazaadenosine specific activity 1 nM/mg/min Mycobacterium tuberculosis ADP + 3-deazaadenosine 5'-phosphate
-
 ?
ATP + 3-deazaadenosine 0.03% of the activity with adenosine Mycobacterium tuberculosis ADP + 3-deaza-AMP
-
 ?
ATP + 3-fluoro-3-deaza-adenosine 0.04% of the activity with adenosine Homo sapiens ADP + 3-fluoro-3-deaza-AMP
-
 ?
ATP + 3-fluoro-3-deaza-adenosine 0.4% of the activity with adenosine Mycobacterium tuberculosis ADP + 3-fluoro-3-deaza-AMP
-
 ?
ATP + 3-fluoro-3-deazaadenosine specific activity 16 nM/mg/min Mycobacterium tuberculosis ADP + 3-fluoro-3-deazaadenosine 5'-phosphate
-
 ?
ATP + 3-fluoro-3-deazaadenosine specific activity: 1 nM/mg/min Homo sapiens ADP + 3-fluoro-3-deazaadenosine 5'-phosphate
-
 ?
ATP + adenosine
-
 Homo sapiens ADP + AMP
-
 ?
ATP + adenosine
-
 Mycobacterium tuberculosis ADP + AMP
-
 ?
ATP + adenosine specific activity: 2700 nM/mg/min Homo sapiens ADP + AMP
-
 ?
ATP + adenosine specific activity: 3700 nM/mg/min Mycobacterium tuberculosis ADP + AMP
-
 ?

Synonyms

Synonyms Comment Organism
Ado kinase
-
 Homo sapiens
Ado kinase
-
 Mycobacterium tuberculosis