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Literature summary for 2.7.1.20 extracted from

  • Iqbal, J.; Burbiel, J.C.; Mueller, C.E.
    Development of off-line and on-line capillary electrophoresis methods for the screening and characterization of adenosine kinase inhibitors and substrates (2006), Electrophoresis, 27, 2505-2517.
    View publication on PubMed
Search for more literature for 2.7.1.20

Inhibitors

Inhibitors Comment Organism Structure
(2S,3S,4R,5R)-2-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol
-
 Bos taurus
4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine
-
 Bos taurus
5-iodotubercidin
-
 Bos taurus
additional information development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-(4-benzylpiperazin-1-yl)adenosine 3% of the activity with adenosine Bos taurus ADP + 2-(4-benzylpiperazin-1-yl)adenosine 5'-phosphate
-
 ?
ATP + 2-(pyrrolidin-1-yl)adenosine 53% of the activity with adenosine Bos taurus ADP + 2-(pyrrolidin-1-yl)adenosine 5'-phosphate
-
 ?
ATP + 2-benzylaminoadenosine 4% of the activity with adenosine Bos taurus ADP + 2-benzylaminoadenosine 5'-phosphate
-
 ?
ATP + 2-cyclohexylaminoadenosine 3% of the activity with adenosine Bos taurus ADP + 2-cyclohexylaminoadenosine 5'-phosphate
-
 ?
ATP + 2-ethylaminoadenosine 3% of the activity with adenosine Bos taurus ADP + 2-ethylaminoadenosine 5'-phosphate
-
 ?
ATP + 2-isopropylamino-N6-isopropyladenosine 81% of the activity with adenosine Bos taurus ADP + 2-isopropylamino-N6-isopropyladenosine 5'-phosphate
-
 ?
ATP + 2-isopropylaminoadenosine 4% of the activity with adenosine Bos taurus ADP + 2-isopropylaminoadenosine 5'-phosphate
-
 ?
ATP + adenosine
-
 Bos taurus ADP + AMP
-
 ?
additional information development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis Bos taurus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis Bos taurus
0.00000006
-
 (2S,3S,4R,5R)-2-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol Ki-value determined by on-line capillary electrophoresis Bos taurus
0.00000009
-
 (2S,3S,4R,5R)-2-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol Ki-value determined by off-line capillary electrophoresis Bos taurus
0.0000014
-
 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine Ki-value determined by off-line capillary electrophoresis Bos taurus
0.0000017
-
 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine Ki-value determined by on-line capillary electrophoresis Bos taurus
0.0000306
-
 5-iodotubercidin
-
 Bos taurus