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Literature summary for 2.7.1.20 extracted from

  • Luescher, A.; Onal, P.; Schweingruber, A.M.; Maeser, P.
    Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites (2007), Antimicrob. Agents Chemother., 51, 3895-3901.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.20

Application

Application Comment Organism
analysis the coexpression of adenosine kinase TbAK and adenosine transporter gene TbAT1 in Saccharomyces cerevisiae ado1 ade2 double mutants proves to be a convenient tool for testing nucleoside analogues for uptake and activation by Trypanosoma brucei adenosine salvage enzymes Trypanosoma brucei

Cloned(Commentary)

Cloned (Comment) Organism
expresion in Saccharomyces cerevisiae Trypanosoma brucei
expression of TbAK in Saccharomyces cerevisiae complements a null mutation in the adenosine kinase gene ado1. The concomitant expression of TbAK with the Trypanosoma brucei adenosine transporter gene TbAT1 allows Saccharomyces cerevisiae ado1 ade2 double mutants to grow on adenosine as the sole purine source and, at the same time, sensitizes them to adenosine antimetabolites Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Trypanosoma brucei 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma brucei the enzyme plays a role in susceptibility to adenosine antimetabolites ?
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bloodstream form
-
 Trypanosoma brucei
-
procyclic form
-
 Trypanosoma brucei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme plays a role in susceptibility to adenosine antimetabolites Trypanosoma brucei ?
-
 ?

Synonyms

Synonyms Comment Organism
TbAK
-
 Trypanosoma brucei