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Literature summary for 2.7.1.20 extracted from
- Inhibition of adenosine and thymidylate kinases by bisubstrate analogs (1986), J. Biol. Chem., 261, 16410-16413.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine-5'-pentaphospho-5'-adenosine | - |
Homo sapiens |  |
| adenosine-5'-tetraphospho-5'-adenosine | strong inhibition | Homo sapiens | |
| Bisadenylyl polyphosphates | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | requirement | Homo sapiens | |
| Mg2+ | optimal at Mg: ATP ratio 1 | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + adenosine = ADP + AMP | mechanism | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + adenosine | - |
Homo sapiens | ADP + AMP | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00003 | - |
adenosine-5'-tetraphospho-5'-adenosine | pH 7.4, 37ºC | Homo sapiens | |
| 0.000073 | - |
adenosine-5'-pentaphospho-5'-adenosine | pH 7.4, 37ºC | Homo sapiens | |
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