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Literature summary for 2.7.1.190 extracted from

  • Toth, M.; Frase, H.; Antunes, N.T.; Vakulenko, S.B.
    Novel aminoglycoside 2-phosphotransferase identified in a gram-negative pathogen (2013), Antimicrob. Agents Chemother., 57, 452-457.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
lividomycin A
-
Campylobacter jejuni
neamine
-
Campylobacter jejuni
neomycin B
-
Campylobacter jejuni
paromomycin
-
Campylobacter jejuni

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00055
-
kanamycin B pH 7.0, 22°C Campylobacter jejuni
0.0007
-
gentamicin C pH 7.0, 22°C Campylobacter jejuni
0.0008
-
GTP pH 7.0, 22°C Campylobacter jejuni
0.001
-
tobramycin above 0.001, pH 7.0, 22°C Campylobacter jejuni
0.0011
-
kanamycin A pH 7.0, 22°C Campylobacter jejuni
0.0012
-
dibekacin pH 7.0, 22°C Campylobacter jejuni
0.0016
-
sisomicin pH 7.0, 22°C Campylobacter jejuni
0.0062
-
arbekacin pH 7.0, 22°C Campylobacter jejuni
0.01
-
netilmicin pH 7.0, 22°C Campylobacter jejuni
0.26
-
amikacin pH 7.0, 22°C Campylobacter jejuni
0.56
-
isepamicin pH 7.0, 22°C Campylobacter jejuni
2
-
ATP pH 7.0, 22°C Campylobacter jejuni

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni Q4VR94
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + gentamicin
-
Campylobacter jejuni ADP + gentamicin 2''-phosphate GTP is preferred over ATP ?
GTP + amikacin
-
Campylobacter jejuni GDP + amikacin 2''-phosphate
-
?
GTP + arbekacin
-
Campylobacter jejuni GDP + arbekacin 2''-phosphate
-
?
GTP + dibekacin
-
Campylobacter jejuni GDP + dibekacin 2''-phosphate
-
?
GTP + gentamicin C
-
Campylobacter jejuni GDP + gentamicin C 2''-phosphate GTP is preferred over ATP ?
GTP + isepamicin
-
Campylobacter jejuni GDP + isepamicin 2''-phosphate
-
?
GTP + kanamycin A
-
Campylobacter jejuni GDP + kanamycin A 2''-phosphate
-
?
GTP + kanamycin B
-
Campylobacter jejuni GDP + kanamycin B 2''-phosphate
-
?
GTP + netilmicin
-
Campylobacter jejuni GDP + netilmicin 2''-phosphate
-
?
GTP + sisomicin
-
Campylobacter jejuni GDP + sisomicin 2''-phosphate
-
?
GTP + tobramycin
-
Campylobacter jejuni GDP + tobramycin 2''-phosphate
-
?
additional information no substrates: 4,5-disubstituted antibiotics and the atypical aminoglycoside neamine Campylobacter jejuni ?
-
?

Synonyms

Synonyms Comment Organism
Aph(2'')-If
-
Campylobacter jejuni

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.25
-
isepamicin pH 7.0, 22°C Campylobacter jejuni
0.38
-
ATP pH 7.0, 22°C Campylobacter jejuni
0.38
-
kanamycin B pH 7.0, 22°C Campylobacter jejuni
0.4
-
GTP pH 7.0, 22°C Campylobacter jejuni
0.48
-
tobramycin pH 7.0, 22°C Campylobacter jejuni
0.79
-
dibekacin pH 7.0, 22°C Campylobacter jejuni
1.7
-
kanamycin A pH 7.0, 22°C Campylobacter jejuni
4.3
-
arbekacin pH 7.0, 22°C Campylobacter jejuni
6.5
-
amikacin pH 7.0, 22°C Campylobacter jejuni
8.3
-
gentamicin C pH 7.0, 22°C Campylobacter jejuni
17
-
sisomicin pH 7.0, 22°C Campylobacter jejuni
18
-
netilmicin pH 7.0, 22°C Campylobacter jejuni

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00016
-
neamine pH 7.0, 22°C Campylobacter jejuni
0.00073
-
neomycin B pH 7.0, 22°C Campylobacter jejuni
0.0085
-
paromomycin pH 7.0, 22°C Campylobacter jejuni
0.012
-
lividomycin A pH 7.0, 22°C Campylobacter jejuni

General Information

General Information Comment Organism
physiological function expression in Escherichia coli confers resistance to the 4,6-disubstituted aminoglycosides kanamycin, tobramycin, dibekacin, gentamicin, and sisomicin, but not to arbekacin, amikacin, isepamicin, or netilmicin, but not to any of the 4,5-disubstituted antibiotics tested Campylobacter jejuni

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.19
-
ATP pH 7.0, 22°C Campylobacter jejuni
0.45
-
isepamicin pH 7.0, 22°C Campylobacter jejuni
25
-
amikacin pH 7.0, 22°C Campylobacter jejuni
480
-
tobramycin above 480, pH 7.0, 22°C Campylobacter jejuni
510
-
GTP pH 7.0, 22°C Campylobacter jejuni
660
-
dibekacin pH 7.0, 22°C Campylobacter jejuni
690
-
kanamycin B pH 7.0, 22°C Campylobacter jejuni
690
-
arbekacin pH 7.0, 22°C Campylobacter jejuni
1500
-
kanamycin A pH 7.0, 22°C Campylobacter jejuni
1700
-
netilmicin pH 7.0, 22°C Campylobacter jejuni
11000
-
sisomicin pH 7.0, 22°C Campylobacter jejuni
12000
-
gentamicin C pH 7.0, 22°C Campylobacter jejuni