Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lividomycin A | - |
Campylobacter jejuni | |
neamine | - |
Campylobacter jejuni | |
neomycin B | - |
Campylobacter jejuni | |
paromomycin | - |
Campylobacter jejuni |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00055 | - |
kanamycin B | pH 7.0, 22°C | Campylobacter jejuni | |
0.0007 | - |
gentamicin C | pH 7.0, 22°C | Campylobacter jejuni | |
0.0008 | - |
GTP | pH 7.0, 22°C | Campylobacter jejuni | |
0.001 | - |
tobramycin | above 0.001, pH 7.0, 22°C | Campylobacter jejuni | |
0.0011 | - |
kanamycin A | pH 7.0, 22°C | Campylobacter jejuni | |
0.0012 | - |
dibekacin | pH 7.0, 22°C | Campylobacter jejuni | |
0.0016 | - |
sisomicin | pH 7.0, 22°C | Campylobacter jejuni | |
0.0062 | - |
arbekacin | pH 7.0, 22°C | Campylobacter jejuni | |
0.01 | - |
netilmicin | pH 7.0, 22°C | Campylobacter jejuni | |
0.26 | - |
amikacin | pH 7.0, 22°C | Campylobacter jejuni | |
0.56 | - |
isepamicin | pH 7.0, 22°C | Campylobacter jejuni | |
2 | - |
ATP | pH 7.0, 22°C | Campylobacter jejuni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Campylobacter jejuni | Q4VR94 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + gentamicin | - |
Campylobacter jejuni | ADP + gentamicin 2''-phosphate | GTP is preferred over ATP | ? | |
GTP + amikacin | - |
Campylobacter jejuni | GDP + amikacin 2''-phosphate | - |
? | |
GTP + arbekacin | - |
Campylobacter jejuni | GDP + arbekacin 2''-phosphate | - |
? | |
GTP + dibekacin | - |
Campylobacter jejuni | GDP + dibekacin 2''-phosphate | - |
? | |
GTP + gentamicin C | - |
Campylobacter jejuni | GDP + gentamicin C 2''-phosphate | GTP is preferred over ATP | ? | |
GTP + isepamicin | - |
Campylobacter jejuni | GDP + isepamicin 2''-phosphate | - |
? | |
GTP + kanamycin A | - |
Campylobacter jejuni | GDP + kanamycin A 2''-phosphate | - |
? | |
GTP + kanamycin B | - |
Campylobacter jejuni | GDP + kanamycin B 2''-phosphate | - |
? | |
GTP + netilmicin | - |
Campylobacter jejuni | GDP + netilmicin 2''-phosphate | - |
? | |
GTP + sisomicin | - |
Campylobacter jejuni | GDP + sisomicin 2''-phosphate | - |
? | |
GTP + tobramycin | - |
Campylobacter jejuni | GDP + tobramycin 2''-phosphate | - |
? | |
additional information | no substrates: 4,5-disubstituted antibiotics and the atypical aminoglycoside neamine | Campylobacter jejuni | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Aph(2'')-If | - |
Campylobacter jejuni |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.25 | - |
isepamicin | pH 7.0, 22°C | Campylobacter jejuni | |
0.38 | - |
ATP | pH 7.0, 22°C | Campylobacter jejuni | |
0.38 | - |
kanamycin B | pH 7.0, 22°C | Campylobacter jejuni | |
0.4 | - |
GTP | pH 7.0, 22°C | Campylobacter jejuni | |
0.48 | - |
tobramycin | pH 7.0, 22°C | Campylobacter jejuni | |
0.79 | - |
dibekacin | pH 7.0, 22°C | Campylobacter jejuni | |
1.7 | - |
kanamycin A | pH 7.0, 22°C | Campylobacter jejuni | |
4.3 | - |
arbekacin | pH 7.0, 22°C | Campylobacter jejuni | |
6.5 | - |
amikacin | pH 7.0, 22°C | Campylobacter jejuni | |
8.3 | - |
gentamicin C | pH 7.0, 22°C | Campylobacter jejuni | |
17 | - |
sisomicin | pH 7.0, 22°C | Campylobacter jejuni | |
18 | - |
netilmicin | pH 7.0, 22°C | Campylobacter jejuni |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00016 | - |
neamine | pH 7.0, 22°C | Campylobacter jejuni | |
0.00073 | - |
neomycin B | pH 7.0, 22°C | Campylobacter jejuni | |
0.0085 | - |
paromomycin | pH 7.0, 22°C | Campylobacter jejuni | |
0.012 | - |
lividomycin A | pH 7.0, 22°C | Campylobacter jejuni |
General Information | Comment | Organism |
---|---|---|
physiological function | expression in Escherichia coli confers resistance to the 4,6-disubstituted aminoglycosides kanamycin, tobramycin, dibekacin, gentamicin, and sisomicin, but not to arbekacin, amikacin, isepamicin, or netilmicin, but not to any of the 4,5-disubstituted antibiotics tested | Campylobacter jejuni |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.19 | - |
ATP | pH 7.0, 22°C | Campylobacter jejuni | |
0.45 | - |
isepamicin | pH 7.0, 22°C | Campylobacter jejuni | |
25 | - |
amikacin | pH 7.0, 22°C | Campylobacter jejuni | |
480 | - |
tobramycin | above 480, pH 7.0, 22°C | Campylobacter jejuni | |
510 | - |
GTP | pH 7.0, 22°C | Campylobacter jejuni | |
660 | - |
dibekacin | pH 7.0, 22°C | Campylobacter jejuni | |
690 | - |
kanamycin B | pH 7.0, 22°C | Campylobacter jejuni | |
690 | - |
arbekacin | pH 7.0, 22°C | Campylobacter jejuni | |
1500 | - |
kanamycin A | pH 7.0, 22°C | Campylobacter jejuni | |
1700 | - |
netilmicin | pH 7.0, 22°C | Campylobacter jejuni | |
11000 | - |
sisomicin | pH 7.0, 22°C | Campylobacter jejuni | |
12000 | - |
gentamicin C | pH 7.0, 22°C | Campylobacter jejuni |