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Literature summary for 2.7.1.19 extracted from

  • Lebreton, S.; Graciet, E.; Gontero, B.
    Modulation, via protein-protein interactions, of glyceraldehyde-3-phosphate dehydrogenase activity through redox phosphoribulokinase regulation (2003), J. Biol. Chem., 278, 12078-12084.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol reduced form Chlamydomonas reinhardtii
thioredoxin reduced form, regulates activity via reversible reduction Chlamydomonas reinhardtii

Inhibitors

Inhibitors Comment Organism Structure
cystine oxidized form, inhibition almost completely reversible by addition of reduced dithiothreitol Chlamydomonas reinhardtii
glutathione oxidized form, inhibition almost completely reversible by addition of reduced dithiothreitol Chlamydomonas reinhardtii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-ribulose 5-phosphate Chlamydomonas reinhardtii part of the Calvin cycle (reductive pentose phosphate pathway), involved in CO2 fixation in photosynthetic organisms ADP + D-ribulose 1,5-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Chlamydomonas reinhardtii
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-
-

Purification (Commentary)

Purification (Comment) Organism
glyceraldehyde-3-phosphate dehydrogenase/CP12/phosphoribulokinase complex Chlamydomonas reinhardtii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-ribulose 5-phosphate
-
Chlamydomonas reinhardtii ADP + D-ribulose 1,5-bisphosphate
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?
ATP + D-ribulose 5-phosphate part of the Calvin cycle (reductive pentose phosphate pathway), involved in CO2 fixation in photosynthetic organisms Chlamydomonas reinhardtii ADP + D-ribulose 1,5-bisphosphate
-
?

Subunits

Subunits Comment Organism
multimer glyceraldehyde-3-phosphate dehydrogenase/CP12/phosphoribulokinase complex, native form of enzyme Chlamydomonas reinhardtii

Synonyms

Synonyms Comment Organism
glyceraldehyde-3-phosphate dehydrogenase/CP12/phosphoribulokinase glyceraldehyde-3-phosphate dehydrogenase and phosphoribulokinase form a supramolecular complex with the regulatory peptide CP12, both enzyme activities strongly dependent on complex formation Chlamydomonas reinhardtii