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Literature summary for 2.7.1.189 extracted from

  • Torres-Escobar, A.; Juarez-Rodriguez, M.D.; Lamont, R.J.; Demuth, D.R.
    Transcriptional regulation of Aggregatibacter actinomycetemcomitans lsrACDBFG and lsrRK operons and their role in biofilm formation (2013), J. Bacteriol., 195, 56-65.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.189

Cloned(Commentary)

Cloned (Comment) Organism
gene lsrK, encoded in the lsrKR operon where lsrK codes for an AI-2 kinase and lsrR encodes a repressor of the lsr operon, sequences important for the optimal transcription of lsrRK are located between -89 and -255 bp. LsrR regulates the expression of both lsrACDBFG and lsrRK operons. Transcription of the lsr locus is complex and may be driven by several promoters Aggregatibacter actinomycetemcomitans

Protein Variants

Protein Variants Comment Organism
additional information generation of chromosomal lsrK deletion (DELTAlsrK), or a chromosomal lsrRK double-deletion (DELTAlsrRK), the transcriptional activities of lsrR-P and lsrA-P do not differ significantly in the wild-type and lsrK-deficient backgrounds, while in the absence of LsrR, the transcriptional activity of both lsrR-P and lsrA-P is increased relative to that of the wild-type strain Aggregatibacter actinomycetemcomitans

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ rrequired Aggregatibacter actinomycetemcomitans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + autoinducer-2 Aggregatibacter actinomycetemcomitans i.e. AI-2 ADP + phosphorylated autoinducer-2
-
 ?

Organism

Organism UniProt Comment Textmining
Aggregatibacter actinomycetemcomitans
-
 gene lsrK in the lsrRK operon
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + autoinducer-2 i.e. AI-2 Aggregatibacter actinomycetemcomitans ADP + phosphorylated autoinducer-2
-
 ?

Synonyms

Synonyms Comment Organism
AI-2 kinase
-
 Aggregatibacter actinomycetemcomitans
lsrK
-
 Aggregatibacter actinomycetemcomitans

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Aggregatibacter actinomycetemcomitans

Expression

Organism Comment Expression
Aggregatibacter actinomycetemcomitans LsrR regulates the expression of both lsrACDBFG and lsrRK operons additional information

General Information

General Information Comment Organism
physiological function genes lsrK and crp are required for optimal biofilm formation by Aggregatibacter actinomycetemcomitans. Another kinase is capable of phosphorylating AI-2 in Aggregatibacter actinomycetemcomitans in the absence of LsrK or enzyme LsrK is not essential for regulating the lsrACDBFG and lsrRK operons in AAggregatibacter actinomycetemcomitans Aggregatibacter actinomycetemcomitans