Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + autoinducer-2 | Escherichia coli | i.e. AI-2 | ADP + phosphorylated autoinducer-2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
gene lsrK | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + autoinducer-2 | i.e. AI-2 | Escherichia coli | ADP + phosphorylated autoinducer-2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lsrK | - |
Escherichia coli |
LsrK kinase | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
malfunction | no induction of the lsr promoter occurs in the lsrK mutant strain, since the lsr promoter is activated by phosphorylated autoinducer-2. Intracellular accumulation of phosphorylated autoinducer-2 is not observed in a lsrK mutant | Escherichia coli |
metabolism | autoinducer 2, AI-2, is imported by the Lsr and is phosphorylated by the LsrK kinase, and AI-2-phosphate is the inducer of the lsr operon. LsrK is necessary for the phosphorylation of AI-2, AI-2 is not phosphorylated by phosphoenolpyruvate phosphotransferase system, which is involved in the AI-2 internalization. Lsr-mediated transport and processing of AI-2 in Escherichia coli, overview | Escherichia coli |
physiological function | enzyme LsrK activity, namely, AI-2 phosphorylation, is required to sequester the signal in the cytoplasm, independently of the mechanism of AI-2 internalization | Escherichia coli |