BRENDA - Enzyme Database
show all sequences of 2.7.1.173

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

Sociali, G.; Raffaghello, L.; Magnone, M.; Zamporlini, F.; Emionite, E.; Sturla, L.; Bianchi, G.; Vigliarolo, T.; Nahimana, A.; Nencioni, A.; Raffaelli, N.; Bruzzone, S; Oncotarget 7, 2968-2984 (2016)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene NRK1, quantitative real-time PCR enzyme expression analysis
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
additional information
enzyme NRK1 specific silencing in human ovarian carcinoma cell line OVCAR-3 by NRK1-specific siRNA
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
the main NRK activity in human OVCAR-3 cells is due to the expression of enzyme NRK1
?
-
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-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9NWW6
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
ovarian carcinoma cell
-
Homo sapiens
-
OVCAR-3 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the main NRK activity in human OVCAR-3 cells is due to the expression of enzyme NRK1
739212
Homo sapiens
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
gene NRK1, quantitative real-time PCR enzyme expression analysis
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
enzyme NRK1 specific silencing in human ovarian carcinoma cell line OVCAR-3 by NRK1-specific siRNA
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
the main NRK activity in human OVCAR-3 cells is due to the expression of enzyme NRK1
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
ovarian carcinoma cell
-
Homo sapiens
-
OVCAR-3 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the main NRK activity in human OVCAR-3 cells is due to the expression of enzyme NRK1
739212
Homo sapiens
?
-
-
-
-
General Information
General Information
Commentary
Organism
malfunction
in NRK1-silenced cells, both nicotinamide riboside- and NMN-mediated rescue from FK866-induced NAD+ depletion and cell death are potently and significantly reduced, overview
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
in NRK1-silenced cells, both nicotinamide riboside- and NMN-mediated rescue from FK866-induced NAD+ depletion and cell death are potently and significantly reduced, overview
Homo sapiens
Other publictions for EC 2.7.1.173
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739212
Sociali
Antitumor effect of combined N ...
Homo sapiens
Oncotarget
7
2968-2984
2016
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738213
Zamporlini
Novel assay for simultaneous m ...
Homo sapiens
FEBS J.
281
5104-5119
2014
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698901
Belenky
Nicotinamide riboside and nico ...
Saccharomyces cerevisiae
J. Biol. Chem.
284
158-164
2009
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3
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718225
Matsui
Nicotinate riboside salvage in ...
Vigna radiata var. radiata
Plant Physiol. Biochem.
46
104-108
2008
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682879
Khan
Crystal structure of human nic ...
Homo sapiens
Structure
15
1005-1013
2007
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718250
Tempel
Nicotinamide riboside kinase s ...
Homo sapiens
PLoS Biol.
5
e263
2007
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1
5
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12
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