BRENDA - Enzyme Database
show all sequences of 2.7.1.173

Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism

Belenky, P.; Christensen, K.C.; Gazzaniga, F.; Pletnev, A.A.; Brenner, C.; J. Biol. Chem. 284, 158-164 (2009)

Data extracted from this reference:

Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + beta-D-ribosylnicotinamide
Saccharomyces cerevisiae
-
ADP + nicotinamide beta-D-ribonucleotide
-
-
?
ATP + beta-D-ribosylnicotinamide
Saccharomyces cerevisiae BY4742
-
ADP + nicotinamide beta-D-ribonucleotide
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Saccharomyces cerevisiae
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + beta-D-ribosylnicotinamide
-
698901
Saccharomyces cerevisiae
ADP + nicotinamide beta-D-ribonucleotide
-
-
-
?
ATP + beta-D-ribosylnicotinamide
-
698901
Saccharomyces cerevisiae BY4742
ADP + nicotinamide beta-D-ribonucleotide
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Saccharomyces cerevisiae
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Saccharomyces cerevisiae
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + beta-D-ribosylnicotinamide
Saccharomyces cerevisiae
-
ADP + nicotinamide beta-D-ribonucleotide
-
-
?
ATP + beta-D-ribosylnicotinamide
Saccharomyces cerevisiae BY4742
-
ADP + nicotinamide beta-D-ribonucleotide
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + beta-D-ribosylnicotinamide
-
698901
Saccharomyces cerevisiae
ADP + nicotinamide beta-D-ribonucleotide
-
-
-
?
ATP + beta-D-ribosylnicotinamide
-
698901
Saccharomyces cerevisiae BY4742
ADP + nicotinamide beta-D-ribonucleotide
-
-
-
?
General Information
General Information
Commentary
Organism
metabolism
nicotinamide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway initiated by splitting the nucleoside into a nicotinamide base followed by nicotinamide salvage. Yeast nicotinic acid riboside utilization largely depends on uridine hydrolase and nicotinamide riboside kinase, and nicotinic acid riboside bioavailability is increased by ester modification
Saccharomyces cerevisiae
additional information
comparison to the Nrk-independent utilization pathway of nicotinamide riboside in yeast, overview
Saccharomyces cerevisiae
physiological function
nicotinamide riboside kinase increases the NAD+ levels via convertion of the substrate nicotinamide riboside and thereby extending replicative lifespan and increases Sir2-dependent gene silencing
Saccharomyces cerevisiae
General Information (protein specific)
General Information
Commentary
Organism
metabolism
nicotinamide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway initiated by splitting the nucleoside into a nicotinamide base followed by nicotinamide salvage. Yeast nicotinic acid riboside utilization largely depends on uridine hydrolase and nicotinamide riboside kinase, and nicotinic acid riboside bioavailability is increased by ester modification
Saccharomyces cerevisiae
additional information
comparison to the Nrk-independent utilization pathway of nicotinamide riboside in yeast, overview
Saccharomyces cerevisiae
physiological function
nicotinamide riboside kinase increases the NAD+ levels via convertion of the substrate nicotinamide riboside and thereby extending replicative lifespan and increases Sir2-dependent gene silencing
Saccharomyces cerevisiae
Other publictions for EC 2.7.1.173
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739212
Sociali
Antitumor effect of combined N ...
Homo sapiens
Oncotarget
7
2968-2984
2016
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-
1
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1
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1
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1
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2
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1
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1
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1
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1
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2
-
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1
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-
-
-
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1
1
-
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-
738213
Zamporlini
Novel assay for simultaneous m ...
Homo sapiens
FEBS J.
281
5104-5119
2014
-
1
-
-
-
-
-
-
-
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1
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8
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2
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1
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8
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-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
698901
Belenky
Nicotinamide riboside and nico ...
Saccharomyces cerevisiae
J. Biol. Chem.
284
158-164
2009
-
-
-
-
-
-
-
-
-
1
-
2
-
1
-
-
-
-
-
-
-
-
2
-
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-
-
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-
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1
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1
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1
-
2
-
-
-
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
718225
Matsui
Nicotinate riboside salvage in ...
Vigna radiata var. radiata
Plant Physiol. Biochem.
46
104-108
2008
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
1
-
-
3
1
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
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1
-
1
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-
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1
-
3
1
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2
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1
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-
1
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-
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1
1
-
-
-
682879
Khan
Crystal structure of human nic ...
Homo sapiens
Structure
15
1005-1013
2007
-
-
1
1
-
-
-
-
-
1
-
1
-
1
-
-
1
1
-
-
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-
4
1
1
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-
1
-
-
1
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-
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1
1
1
-
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-
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-
1
-
1
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1
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4
1
1
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1
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1
1
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-
718250
Tempel
Nicotinamide riboside kinase s ...
Homo sapiens
PLoS Biol.
5
e263
2007
-
-
1
1
5
-
-
12
-
1
-
4
-
2
-
-
1
-
-
-
-
-
18
1
1
-
-
12
1
-
-
3
-
-
-
-
-
2
4
1
5
-
-
-
-
12
-
2
-
4
-
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-
2
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-
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18
2
2
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12
2
-
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-
2
4
-
12
12