Cloned (Comment) | Organism |
---|---|
gene FN3K, DNA and amino acid sequence analysis, genotyping | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | allelic variants of FN3K polymorphisms revealed 13 distinct genotypic variants in a cohort of patients with type 2 diabetes mellitus (T2DM), detection of three polymorphisms associated with the enzymatic activity (rs3859206 and rs2256339 in the promoter region and rs1056534 in exon 6). The FN3K genotype presenting GG at position -385, TT at position -232, and CC at c.900 A, is associated with less severe microangiopathic and macroangiopathic complications as a whole, compared to all other genotypes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
intracellular | - |
Homo sapiens | 5622 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-N6-D-fructosyl-L-lysine | Homo sapiens | - |
ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9H479 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-N6-D-fructosyl-L-lysine | - |
Homo sapiens | ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FN3K | - |
Homo sapiens |
fructosamine-3-kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | polymorphisms of the FN3K gene are associated with variations in HbA1c levels and with the onset of type 2 diabetes mellitus (T2DM) and pathogenic mechanisms related to its complications, role of FN3K polymorphisms in the development of microvascular and macrovascular complications of diabetes, overview. The FN3K genotype presenting GG at position -385, TT at position -232, and CC at c.900 A, is associated with less severe microangiopathic and macroangiopathic complications as a whole, compared to all other genotypes | Homo sapiens |
physiological function | fructosamine-3-kinase (FN3K) is involved in deglycation, active in removing ketoamines, and preventing advanced glycation end product production. Enzyme FN3K is capable of counteracting the effect of hyperglycemia by intervening in protein glycation. The FN3K genetic variability is linked to the enzyme's enzymatic activity and glycated hemoglobin (HbA1c) levels | Homo sapiens |